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Literature summary for 3.4.24.22 extracted from

  • Justilien, V.; Regala, R.; Tseng, I.; Walsh, M.; Batra, J.; Radisky, E.; Murray, N.; Fields, A.
    Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential (2012), PLoS ONE, 7, e35040.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus O55123
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Mus musculus C57BL/6 O55123
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Source Tissue

Source Tissue Comment Organism Textmining
bronchioalveolar stem cell
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 Mus musculus
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CMT-167 cell
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 Mus musculus
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lung
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 Mus musculus
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lung cancer cell enzyme Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Mmp10 and Notch4 expression in primary and metastatic lung tumors Mus musculus
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additional information strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Oncosphere cultures exhibit Mmp10-dependent tumor-initiating activity in vivo Mus musculus
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Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-10
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 Mus musculus
MMP10
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types additional information

General Information

General Information Comment Organism
malfunction RNAi-mediated knockdown of Mmp10 leads to a loss of stem cell marker gene expression and inhibition of oncosphere growth, clonal expansion, and transformed growth in vitro. Enzyme Mmp10-deficient cultures show a severe defect in tumor initiation Mus musculus
additional information strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types Mus musculus
physiological function role for the enzyme in the maintenance, tumorigenicity, and proliferation of mouse lung cancer stem-like cells, overview Mus musculus