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Literature summary for 3.4.24.22 extracted from
- MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer (2009), Exp. Dermatol., 18, 1044-1052.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
K5-IkBa mice | - |
| Mus musculus ICR | - |
K5-IkBa mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| keratinocyte | in dysplastic epithelium MMP-10 is never expressed in basal keratinocytes | Mus musculus | - |
| keratinocyte | of Bowen's disease patients | Homo sapiens | - |
| macrophage | - |
Homo sapiens | - |
| additional information | with increasing epidermal hyperplasia, the amount of inflammatory infiltration increased and MMP-10 is also detected in suprabasal keratinocytes as the mice aged | Mus musculus | - |
| polymorphonuclear leucocyte | - |
Mus musculus | - |
| skin | - |
Mus musculus | - |
| skin | - |
Homo sapiens | - |
| squamous cell carcinoma cell | - |
Mus musculus | - |
| squamous cell carcinoma cell | in situ detection, overview | Homo sapiens | - |
| stratum granulosum | at all ages in normal and acanthotic skin | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP-10 | - |
Mus musculus |
| MMP-10 | - |
Homo sapiens |
| stromelysin-2 | - |
Mus musculus |
| stromelysin-2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. Contribution of MMP-10 to squamous cell cancer development in the FVB/NTg(KRT5-Nfkbia)3Rto mouse line, overview | Mus musculus |
| additional information | MMP-10 is not associated with keratinocyte apoptosis or atypia | Mus musculus |
| physiological function | MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. MMP-10 is expressed in Bowen's disease | Homo sapiens |
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