Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | matrix metalloproteinase MMP-1 zymogen activation by enzyme and other serine proteases is central to endothelial cell-mediated collagen degradation and capillary tube regression in 3D collagen matrices | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation of proenzyme by serine proteases such as plasma kallikrein, trypsin, neutrophil elastase, cathepsin G, tryptase or chymase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | proenzyme expression is markedly induced in endothelial cells undergoing capillary tube morphogenesis. Enzyme-induced activation of matrix metalloproteinase MMP-1 correlates with tube regression and gel contraction | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | matrix metalloproteinase MMP-1 zymogen activation by enzyme and other serine proteases is central to endothelial cell-mediated collagen degradation and capillary tube regression in 3D collagen matrices | Homo sapiens | ? | - |
? | |
proMMP-1 + H2O | - |
Homo sapiens | MMP-1 + propeptide | - |
? |