Literature summary for 3.4.24.21 extracted from

Sarkar, I.
To compare the active sites of a series of astacin family proteases by multiple sequence alignment and homology modelling methods (2015), Comput. Adv. Commun. Circ. Syst.: ICCACCS 2014, 335, 145-150 .

No PubMed abstract available

Search for more literature for 3.4.24.21

Cloned(Commentary)

Cloned (Comment)	Organism
gene BMP1, sequence comparison with meprin A (EC 3.4.24.18) and meprin B (EC 3.4.24.63) of the astacin enzyme family	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibitor coordinates the catalytic zinc ion via carbonyl oxygen of glycine and O atom of hydroxamic acid	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	inhibitor coordinates the catalytic zinc ion via carbonyl oxygen of glycine and O atom of hydroxamic acid	Homo sapiens
Zn2+	a zinc metalloproteinase, catalytic zinc ion	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P13497	-	-

Synonyms

Synonyms	Comment	Organism
BMP-1	-	Homo sapiens
bone morphogenetic protein 1	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the astacin family of zinc-dependent endopeptidase. All the members of this family have a protease domain containing approximately 200 amino acids, which shares an amino-acid sequence similarity of 29-99%. Astacin family members are characterized by a unique 18 amino acid signature sequence HEXXHXXGFXHEXXRXDR containing the Zn binding motif HEXXH present in all metalloendopeptidases. Most of the known family members contain a COOH terminal to the protease domain. They are found to contain one or more copies of the EGF (epidermal growth factor) like E and/or CUB (complement subcomponents) domain. Differences in the active sites and inhibitor sites of astacin/BMP1, human meprin alpha, and human meprin beta, overview. The subsites S1, S2, S3, S1', S2', S3' have differences in amino acid residues. Structure homology modelling	Homo sapiens

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Release 2023.1 (January 2023)