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Literature summary for 3.4.24.21 extracted from

  • Schneppenheim, J.; Scharfenberg, F.; Lucius, R.; Becker-Pauly, C.; Arnold, P.
    Meprin beta and BMP-1 are differentially regulated by CaCl2 (2017), Cell Calcium, 65, 8-13 .
    View publication on PubMed
Search for more literature for 3.4.24.21

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular BMP-1 is directly secreted into extracellular space. The protease domain contains a rather large 98 amino acid long pro-peptide Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, a positive regulator of BMP-1 Homo sapiens
Zn2+ a zinc-dependent metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-collagen I + H2O Homo sapiens maturation collagen I + collagen I propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P13497
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification in active BMP-1 an additional ion seems to be coordinated by several residues. The new N-terminus that results from intracellular activation of BMP-1, Ala121, is acetylated (N-Ace A121) and, together with Glu224, Asp312 and three water molecules, it interacts with this ion, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-collagen I + H2O maturation Homo sapiens collagen I + collagen I propeptide
-
 ?
pro-collagen I + H2O cleavage of the C-terminal pro-domain Homo sapiens collagen I + collagen I propeptide
-
 ?

Subunits

Subunits Comment Organism
More the protease domain is followed by two CUB-domains (complement C1r/C1s, Uegf, BMP-1)(CUB1+2), an EGF-like domain and another CUB domain Homo sapiens

Synonyms

Synonyms Comment Organism
BMP-1
-
 Homo sapiens
bone morphogenetic protein 1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction ablation of one of the two zinc metalloproteinases, meprin beta and BMP-1, leads to different collagen I associated phenotypes in vivo Homo sapiens
metabolism the zinc metalloproteinases meprin beta and BMP-1 are differentially regulated by CaCl2, overview Homo sapiens
additional information structural differences between meprin beta (EC 3.4.24.63) and BMP-1. Molecular dynamics simulation Homo sapiens
physiological function an increase in activity is reported under increasing calcium concentrations for BMP-1 Homo sapiens