Cloned (Comment) | Organism |
---|---|
gene xh2, DNA and amino acid sequence determination and analysis, sequence comparison, expression analysis | Xenopus laevis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockdown | Xenopus laevis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | Q63ZG3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hatching gland | the enzyme Xhe2 is exclusively expressed in hatching gland cells as they first emerge at the lateral edge of the anterior neural plate, and persists in this tissue up to the tadpole stage | Xenopus laevis | - |
additional information | developmental expression of enzyme Xhe2 and its regulation by transcription factor Pax3, overview | Xenopus laevis | - |
Synonyms | Comment | Organism |
---|---|---|
Xhe2 | - |
Xenopus laevis |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of the astacin family of metalloproteases | Xenopus laevis |
metabolism | the enzyme Xhe2 expression depends entirely on transcription factor Pax3 function. Pax3 can induce premature hatching through the upregulation of several proteolytic enzymes including enzyme Xhe2 | Xenopus laevis |
physiological function | the enzyme promotes Xenopus hatching. Xhe2 overexpression is sufficient to induce early hatching, indicating that Xhe2 is one of the key components of the degradation mechanism responsible for breaking down the vitelline membrane | Xenopus laevis |