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Literature summary for 3.4.24.21 extracted from

  • Hong, C.S.; Saint-Jeannet, J.P.
    Xhe2 is a member of the astacin family of metalloproteases that promotes Xenopus hatching (2014), Genesis, 52, 946-951.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene xh2, DNA and amino acid sequence determination and analysis, sequence comparison, expression analysis Xenopus laevis

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockdown Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q63ZG3
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Source Tissue

Source Tissue Comment Organism Textmining
hatching gland the enzyme Xhe2 is exclusively expressed in hatching gland cells as they first emerge at the lateral edge of the anterior neural plate, and persists in this tissue up to the tadpole stage Xenopus laevis
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additional information developmental expression of enzyme Xhe2 and its regulation by transcription factor Pax3, overview Xenopus laevis
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Synonyms

Synonyms Comment Organism
Xhe2
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Xenopus laevis

General Information

General Information Comment Organism
evolution the enzyme is a member of the astacin family of metalloproteases Xenopus laevis
metabolism the enzyme Xhe2 expression depends entirely on transcription factor Pax3 function. Pax3 can induce premature hatching through the upregulation of several proteolytic enzymes including enzyme Xhe2 Xenopus laevis
physiological function the enzyme promotes Xenopus hatching. Xhe2 overexpression is sufficient to induce early hatching, indicating that Xhe2 is one of the key components of the degradation mechanism responsible for breaking down the vitelline membrane Xenopus laevis