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Literature summary for 3.4.24.19 extracted from

  • Canty-Laird, E.G.; Lu, Y.; Kadler, K.E.
    Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ (2012), Biochem. J., 441, 707-717.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.19

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Gallus gallus
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Mus musculus
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
trans-Golgi network brefeldin A treatment of tendon explant cultures shows that that C-proteinase activity is restricted to the trans-Golgi network in embryonic chick tendon fibroblasts. In late embryonic tendon, C-proteinase activity is detected in trans-Golgi network and pre-trans-Golgi network compartments Gallus gallus 5802
-
trans-Golgi network postnatal rat tail and postnatal mouse tail tendon, C-proteinase activity is detected in trans-Golgi network and pre-trans-Golgi network compartments Mus musculus 5802
-
trans-Golgi network postnatal rat tail and postnatal mouse tail tendon, C-proteinase activity is detected in trans-Golgi network and pre-trans-Golgi network compartments Rattus norvegicus 5802
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen I + H2O Gallus gallus
-
 pCcollagen + oligopeptide
-
 ?
procollagen I + H2O Mus musculus
-
 pCcollagen + oligopeptide
-
 ?
procollagen I + H2O Rattus norvegicus
-
 pCcollagen + oligopeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
tail
-
 Mus musculus
-
tail
-
 Rattus norvegicus
-
tendon metatarsal tendons obtained from E13 chick embryos Gallus gallus
-
tendon tail tendons are obtained from 3-week-old CD1 mice Mus musculus
-
tendon tail tendons are obtained from 3-week-old CD1 mice Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen I + H2O
-
 Gallus gallus pCcollagen + oligopeptide
-
 ?
procollagen I + H2O
-
 Mus musculus pCcollagen + oligopeptide
-
 ?
procollagen I + H2O
-
 Rattus norvegicus pCcollagen + oligopeptide
-
 ?

Synonyms

Synonyms Comment Organism
Procollagen C-proteinase
-
 Gallus gallus
Procollagen C-proteinase
-
 Mus musculus
Procollagen C-proteinase
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism the N-propeptides are removed first, most probably in the Golgi or in the ERGIC (ER-Golgi intermediate compartment). In contrast, the C-propeptides are cleaved in a post-Golgi compartment Gallus gallus
metabolism the N-propeptides are removed first, most probably in the Golgi or in the ERGIC (ER-Golgi intermediate compartment). In contrast, the C-propeptides are cleaved in a post-Golgi compartment Mus musculus
metabolism the N-propeptides are removed first, most probably in the Golgi or in the ERGIC (ER–Golgi intermediate compartment). In contrast, the C-propeptides are cleaved in a post-Golgi compartment Rattus norvegicus