Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Enhancer glycoprotein | stimulates activity | Homo sapiens | |
TGFbeta | increases the expression of BMP-1 and Tld in human dermal fibroblasts | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | involved in deposition of collagen fibrils in the extracellular matrix following processing of procollagen propeptides, dorsoventral patterning through cleavage of chordin, collagen and elastin cross-linking by processing of inactive precursors of lysyl oxidases, proteoglycan maturation and assembly of the dermal-epidermal junction by processing of laminin 5 chains and cleaving the C-propeptide of type VII procollagen | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in baculovirus-infected Sf21 insect cells, HT-180 cells, 293-EBNA cells or COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | homozygous null mice lacking PCBs encoded by BMP-1 are perinatally lethal and have reduced ossification of skull bones and defects in formation of the ventral body wall, procollagen processing and collagen fibrillogenesis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Homo sapiens | |
Ac-Met-Val-Gly-Asp-Asp-Pro-Tyr-Asn-NH2 | weak inhibitor | Homo sapiens | |
acidic dipeptide hydroxamate derivates | mimic the location of aspartic acid residues in the P1' and P2' positions of the PCP cleavage site in procollagen | Homo sapiens | |
alpha2-Macroglobulin | - |
Homo sapiens | |
Arg | inhibits at 5-10 mM | Homo sapiens | |
CdCl2 | - |
Homo sapiens | |
concanavalin A | - |
Homo sapiens | |
CuCl2 | inhibits at 0.01-0.1 mM | Homo sapiens | |
di-/tripeptidic hydroxamic acid derivates | - |
Homo sapiens | |
DTT | - |
Homo sapiens | |
EDTA | - |
Homo sapiens | |
EGTA | - |
Homo sapiens | |
Lys | inhibits at 5-10 mM | Homo sapiens | |
N-ethylmaleimide | inhibits at 20 mM | Homo sapiens | |
NaCl | inhibits at 200-500 mM | Homo sapiens | |
small molecule ox(adi)azolyl-hydroxamic acid derivates | - |
Homo sapiens | |
sulfonamide hydrxamate derivates of ornithine analogs | - |
Homo sapiens | |
Tris-HCl buffer | inhibits at 200-500 mM | Homo sapiens | |
Tyr-Tyr-Arg-Ala-Asp-Asp-Ala | weak inhibitor | Homo sapiens | |
ZnCl2 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Strongylocentrotus purpuratus | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required for activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
10700 | - |
immunoblotting, XBMP1-B in adults | Xenopus laevis |
63000 | - |
XBMP1-A in unfertilized eggs | Xenopus laevis |
71890 | - |
calculated | Strongylocentrotus purpuratus |
80000 | - |
SDS-PAGE, mature N-gycosylated enzyme | Mus musculus |
80670 | - |
XBMP1-B | Xenopus laevis |
82900 | - |
prepro-BMP1 | Homo sapiens |
100000 | - |
SDS-PAGE, mature N-gycosylated enzyme | Gallus gallus |
110200 | - |
XBMP1-A | Xenopus laevis |
111600 | - |
mTld | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Strongylocentrotus purpuratus | - |
- |
- |
Xenopus laevis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Gallus gallus |
- |
Mus musculus |
by anti-Flag affinity column | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adenocarcinoma cell | gastric epithelial adenocarcinoma stimulated with Helicobacter pylori | Homo sapiens | - |
articular cartilage | - |
Homo sapiens | - |
articular cartilage | - |
Rattus norvegicus | - |
blastula | - |
Xenopus laevis | - |
blood | tumor endothelial cells of malignant colorectal tissues | Homo sapiens | - |
brain | mTld | Homo sapiens | - |
chondrocyte | - |
Homo sapiens | - |
chondrocyte | - |
Rattus norvegicus | - |
dermis | - |
Homo sapiens | - |
egg | - |
Xenopus laevis | - |
embryo | - |
Xenopus laevis | - |
embryo | in both ectodermal and primary mesenchyme cells in hatched blastula stage | Strongylocentrotus purpuratus | - |
embryo | initially expressed at gastrulation stages, later during dorso-ventral patterning of the neural tube in neural crest and ventrally in the caudal notochord and floor plate, and during patterning of the somites | Gallus gallus | - |
embryo | throughout the mesenchyme of developing embryonic tissue | Mus musculus | - |
epiphysis | - |
Homo sapiens | - |
epiphysis | - |
Rattus norvegicus | - |
fibroblast | - |
Mus musculus | - |
fibroblast | - |
Homo sapiens | - |
heart | mTld and BMP-1 | Homo sapiens | - |
hindlimb | - |
Xenopus laevis | - |
kidney | mTld and BMP-1 | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | mTld and BMP-1 | Homo sapiens | - |
lung | mTld and BMP-1 | Homo sapiens | - |
MG-63 cell | - |
Homo sapiens | - |
additional information | in developing membranous and endochondral bones, in sections of murine hind limp and femoral growth plate | Mus musculus | - |
additional information | metaphysis | Homo sapiens | - |
additional information | metaphysis | Rattus norvegicus | - |
osteoblast | - |
Homo sapiens | - |
osteoblast | - |
Rattus norvegicus | - |
osteoclast | - |
Homo sapiens | - |
osteoclast | - |
Rattus norvegicus | - |
placenta | - |
Mus musculus | - |
placenta | mTld and BMP-1 | Homo sapiens | - |
skeletal muscle | mTld and BMP-1 | Homo sapiens | - |
Storage Stability | Organism |
---|---|
-70°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bovine lysyl oxidase-like precursor protein + H2O | cleaved at a Gly-Asp and Ser-Asp bond | Homo sapiens | ? | - |
? | |
chordin + H2O | - |
Homo sapiens | ? | - |
? | |
lamin 5 + H2O | gamma2 chain cleaved at a Gly-Asp bond, also cleavage of alpha3 chain | Homo sapiens | ? | - |
? | |
pC-collagen + H2O | - |
Homo sapiens | ? | - |
? | |
pro-lysyl oxidase + H2O | cleaved at site Met-Val-Gyl-Asp-Asp-Pro | Homo sapiens | ? | - |
? | |
probiglycan + H2O | - |
Homo sapiens | ? | - |
? | |
Procollagen type I + H2O | - |
Homo sapiens | Type I pNcollagen + C-propeptides | - |
? | |
procollagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
procollagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
procollagen type VII + H2O | cleaved at an Ala-Asp bond | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BMP-1 | - |
Gallus gallus |
BMP-1 | - |
Mus musculus |
BMP-1 | - |
Homo sapiens |
bone morphogenetic protein 1 | - |
Gallus gallus |
bone morphogenetic protein 1 | - |
Mus musculus |
bone morphogenetic protein 1 | - |
Homo sapiens |
carboxy-terminal procollagen peptidase | - |
Gallus gallus |
carboxy-terminal procollagen peptidase | - |
Mus musculus |
carboxy-terminal procollagen peptidase | - |
Homo sapiens |
carboxy-terminal procollagen peptidase | - |
Xenopus laevis |
carboxy-terminal procollagen peptidase | - |
Strongylocentrotus purpuratus |
carboxyl-procollagen peptidase | - |
Gallus gallus |
carboxyl-procollagen peptidase | - |
Mus musculus |
carboxyl-procollagen peptidase | - |
Homo sapiens |
carboxyl-procollagen peptidase | - |
Xenopus laevis |
carboxyl-procollagen peptidase | - |
Strongylocentrotus purpuratus |
mammalian tolloid | - |
Mus musculus |
mammalian tolloid | - |
Homo sapiens |
MtlD | - |
Mus musculus |
MtlD | - |
Homo sapiens |
PCP | - |
Gallus gallus |
PCP | - |
Mus musculus |
PCP | - |
Homo sapiens |
PCP | - |
Xenopus laevis |
PCP | - |
Strongylocentrotus purpuratus |
PCP-1 | - |
Gallus gallus |
PCP-1 | - |
Mus musculus |
PCP-1 | - |
Homo sapiens |
PCP-2 | - |
Gallus gallus |
PCP-2 | - |
Mus musculus |
PCP-2 | - |
Homo sapiens |
procollagen C-peptidase | - |
Gallus gallus |
procollagen C-peptidase | - |
Mus musculus |
procollagen C-peptidase | - |
Homo sapiens |
procollagen C-peptidase | - |
Xenopus laevis |
procollagen C-peptidase | - |
Strongylocentrotus purpuratus |
Procollagen C-proteinase | - |
Gallus gallus |
Procollagen C-proteinase | - |
Mus musculus |
Procollagen C-proteinase | - |
Homo sapiens |
Procollagen C-proteinase | - |
Rattus norvegicus |
Procollagen C-proteinase | - |
Xenopus laevis |
Procollagen C-proteinase | - |
Strongylocentrotus purpuratus |
suBMP-1 | - |
Strongylocentrotus purpuratus |
Tld | - |
Gallus gallus |
tolloid | - |
Gallus gallus |
XBMP1-A | - |
Xenopus laevis |
XBMP1-B | - |
Xenopus laevis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 8.5 | - |
Homo sapiens |