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Literature summary for 3.4.24.18 extracted from

  • Breig, O.; Yates, M.; Neaud, V.; Couchy, G.; Grigoletto, A.; Lucchesi, C.; Prox, J.; Zucman-Rossi, J.; Becker-Pauly, C.; Rosenbaum, J.
    Metalloproteinase meprin alpha regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin (2017), Oncotarget, 8, 7839-7851 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.18

Application

Application Comment Organism
pharmacology meprin alpha is a potential target in treatment of hepatocellular carcinoma (HCC), although meprin alpha has a limited effect on HCC cell proliferation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene MEP1A, quantitative RT-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of Mep1A restores a normal cell migration in cells where Reptin is depleted Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent metalloendoprotease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16819
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
hepatocellular carcinoma cell meprin alpha is overexpressed in human hepatocellular carcinoma and its expression correlates with that of reptin Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
additional information meprin alpha mRNA level is 2fold higher in hepatocellular carcinoma samples as compared to non-tumor liver Homo sapiens
-

Synonyms

Synonyms Comment Organism
MEP1A
-
 Homo sapiens
meprin alpha
-
 Homo sapiens
metalloproteinase meprin alpha
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens silencing reptin decreases Mep1A expression and activity down

General Information

General Information Comment Organism
metabolism Mep1A is a target of reptin, a protein that is oncogenic in hepatocellular carcinoma (HCC). Silencing reptin decreases Mep1A expression and activity, without affecting meprin beta (EC 3.4.24.63) Homo sapiens
physiological function Mep1A is overexpressed in most hepatocellular carcinomas and induces hepatocellular carcinoma (HCC) cell migration and invasion. Mep1A expression is regulated by reptin, or RUVBL2, a member of the AAA+ ATPase family. And Mep1A mediates reptin-induced migration. Meprin alpha has a limited effect on HCC cell proliferation Homo sapiens