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Literature summary for 3.4.24.18 extracted from

  • Chaudhuri, A.; Bera, A.K.; Sarkar, I.; Chakraborty, S.
    Insights from analysis of binding sites of human meprins screening of inhibitors by molecular dynamics simulation study (2016), Comb. Chem. High Throughput Screen., 19, 246-258 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
actinonin
-
Homo sapiens
batimastat
-
Homo sapiens
captopril
-
Homo sapiens
cystatin C
-
Homo sapiens
EDTA enzyme binding structure, modelling Homo sapiens
fetuin A
-
Homo sapiens
galardin enzyme binding structure, modelling Homo sapiens
additional information analysis of binding sites of human meprins, screening of inhibitors by molecular dynamics simulation study, molecular docking, overview Homo sapiens
Pro-Leu-Gly-hydroxamate enzyme binding structure, modelling Homo sapiens
Ro-327315
-
Homo sapiens
TAPI-0
-
Homo sapiens
TAPI-2 i.e. tumour necrosis factor alpha protease inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc-dependent metalloprotease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16819
-
-

Synonyms

Synonyms Comment Organism
meprin alpha
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00014
-
galardin pH and temperature not specified in the publication Homo sapiens
0.00053
-
Pro-Leu-Gly-hydroxamate pH and temperature not specified in the publication Homo sapiens
0.74
-
captopril pH and temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
additional information human meprin alpha is modelled using the template structure of astacin Homo sapiens