Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinonin | - |
Homo sapiens | |
actinonin | - |
Mus musculus | |
captopril | - |
Homo sapiens | |
CGS 27023A | - |
Homo sapiens | |
CGS 27023A | - |
Mus musculus | |
CONA 65 | - |
Homo sapiens | |
CONA 65 | - |
Mus musculus | |
CONA 68 | - |
Homo sapiens | |
CONA 68 | - |
Mus musculus | |
CONA 71 | - |
Homo sapiens | |
CONA 71 | - |
Mus musculus | |
CONA 73 | - |
Homo sapiens | |
CONA 73 | - |
Mus musculus | |
doxycycline | - |
Homo sapiens | |
doxycycline | - |
Mus musculus | |
GM6001 | Ilomastat | Homo sapiens | |
GM6001 | Ilomastat | Mus musculus | |
homophenylalanine hydroxamate | - |
Homo sapiens | |
homophenylalanine hydroxamate | - |
Mus musculus | |
Pro-Leu-Gly hydroxamate | - |
Homo sapiens | |
Pro-Leu-Gly hydroxamate | - |
Mus musculus | |
TNF-a processing enzyme inhibitor | TAPI-2 | Homo sapiens | |
TNF-alpha processing enzyme inhibitor | TAPI-2 | Mus musculus | |
tyrosine hydroxamate | - |
Homo sapiens | |
tyrosine hydroxamate | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
protein PTH12-34 | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.0223 | - |
alpha-MSH | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Mus musculus | |
0.0296 | - |
protein GRP | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Mus musculus | |
0.0306 | - |
Substance P | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Mus musculus | |
0.0339 | - |
secretin | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.0413 | - |
Substance P | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.0565 | - |
luteinizing hormone releasing hormone LHRH | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.0672 | - |
protein PTH12-34 | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Mus musculus | |
0.0732 | - |
orcokinin | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.101 | - |
bradykinin | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Mus musculus | |
0.11 | - |
GRP | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.111 | - |
secretin | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Mus musculus | |
0.125 | - |
bradykinin | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.156 | - |
luteinizing hormone releasing hormone LHRH | meprin A hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 for between 8-30 min | Mus musculus | |
0.2 | - |
gastrin | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens | |
0.292 | - |
alpha-MSH | hydrolysis in 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 between 8-30 min | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
86000 | - |
monomeric molecular mass of a meprin alpha-subunit | Mus musculus |
86000 | - |
monomeric molecular mass of a meprin alpha-subunit | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.9 | - |
specific activity of homo-oligomeric meprin A against PTH | Homo sapiens |
4.2 | - |
specific activity of homo-oligomeric meprin A against PTH | Mus musculus |
2700 | - |
specific activity of homo-oligomeric meprin A against gelatin | Homo sapiens |
20500 | - |
specific activity of homo-oligomeric meprin A against azocasein | Mus musculus |
20800 | - |
specific activity of homo-oligomeric meprin A against azocasein | Homo sapiens |
25000 | - |
specific activity of homo-oligomeric meprin A against gelatin | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-MSH + H2O | - |
Mus musculus | ? | - |
? | |
alpha-MSH + H2O | - |
Homo sapiens | ? | - |
? | |
bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
gastrin + H2O | - |
Homo sapiens | ? | - |
? | |
GRP + H2O | - |
Homo sapiens | ? | - |
? | |
luteinizing hormone releasing hormone LHRH + H2O | - |
Mus musculus | ? | - |
? | |
luteinizing hormone releasing hormone LHRH + H2O | - |
Homo sapiens | ? | - |
? | |
orcokinin + H2O | - |
Homo sapiens | ? | - |
? | |
protein GRP + H2O | - |
Mus musculus | ? | - |
? | |
protein GRP + H2O | - |
Homo sapiens | ? | - |
? | |
protein LHRH + H2O | - |
Mus musculus | ? | - |
? | |
protein LHRH + H2O | - |
Homo sapiens | ? | - |
? | |
protein PTH12-34 + H2O | - |
Mus musculus | ? | - |
? | |
protein PTH12-34 + H2O | - |
Homo sapiens | ? | - |
? | |
Secretin + H2O | - |
Mus musculus | ? | - |
? | |
Secretin + H2O | - |
Homo sapiens | ? | - |
? | |
Substance P + H2O | - |
Mus musculus | ? | - |
? | |
Substance P + H2O | - |
Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
gastrin | - |
Homo sapiens | |
3.7 | - |
bradykinin | - |
Homo sapiens | |
4.4 | - |
secretin | - |
Mus musculus | |
4.6 | - |
parathyphoid hormone 12-34 | - |
Homo sapiens | |
5.1 | - |
protein LHRH | - |
Homo sapiens | |
5.2 | - |
Substance P | - |
Homo sapiens | |
6.3 | - |
orcokinin | - |
Homo sapiens | |
8.4 | - |
secretin | - |
Homo sapiens | |
10.5 | - |
protein PTH12-34 | - |
Mus musculus | |
12.1 | - |
Substance P | - |
Mus musculus | |
16.5 | - |
alpha-MSH | - |
Homo sapiens | |
16.6 | - |
bradykinin | - |
Mus musculus | |
19.6 | - |
protein GRP | - |
Homo sapiens | |
24.6 | - |
protein GRP | - |
Mus musculus | |
39.4 | - |
protein LHRH | - |
Mus musculus | |
45.4 | - |
alpha-MSH | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0033 | - |
- |
Mus musculus | CONA 65 | |
0.005 | - |
- |
Homo sapiens | actinonin | |
0.008 | - |
- |
Mus musculus | CGS 27023A | |
0.016 | - |
- |
Homo sapiens | CGS 27023A | |
0.04 | - |
- |
Mus musculus | CONA 68 | |
0.05 | - |
- |
Homo sapiens | CONA 68 | |
0.06 | - |
Ilomastat | Homo sapiens | GM6001 | |
0.065 | - |
- |
Homo sapiens | CONA 73 | |
0.08 | - |
- |
Homo sapiens | TNF-alpha processing enzyme inhibitor | |
0.1 | - |
- |
Homo sapiens | tyrosine hydroxamate | |
0.1 | - |
- |
Homo sapiens | homophenylalanine hydroxamate | |
0.17 | - |
- |
Homo sapiens | CONA 71 | |
0.18 | - |
- |
Mus musculus | actinonin | |
0.25 | - |
- |
Mus musculus | CONA 71 | |
0.31 | - |
- |
Mus musculus | CONA 73 | |
0.4 | - |
- |
Homo sapiens | Pro-Leu-Gly hydroxamate | |
0.6 | - |
Ilomastat | Mus musculus | GM6001 | |
0.8 | - |
- |
Mus musculus | homophenylalanine hydroxamate | |
0.8 | - |
- |
Mus musculus | TNF-alpha processing enzyme inhibitor | |
1.1 | - |
- |
Mus musculus | tyrosine hydroxamate | |
2 | - |
- |
Homo sapiens | CONA 65 | |
12 | - |
- |
Homo sapiens | doxycycline | |
16 | - |
- |
Mus musculus | Pro-Leu-Gly hydroxamate | |
20 | - |
- |
Mus musculus | doxycycline | |
40 | - |
- |
Homo sapiens | captopril |