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Literature summary for 3.4.24.18 extracted from
- Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse (1989), Biochem. J., 264, 335-346.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | renal brush border membrane | Mus musculus | 16020 | - |
| membrane | renal brush border membrane | Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
x * 80000, SDS-PAGE, reducing conditions | Mus musculus |
| 80000 | - |
x * 80000, SDS-PAGE, reducing conditions | Rattus norvegicus |
| 90000 | - |
x * 90000, mouse, SDS-PAGE, reducing conditions | Mus musculus |
| 90000 | - |
x * 90000, mouse, SDS-PAGE, reducing conditions | Rattus norvegicus |
| 220000 | - |
rat, SDS-PAGE, non-reducing conditions | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
meprin A, from male BALB/c | - |
| Rattus norvegicus | - |
endopeptidase-2, male Wistar | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 30% Asp-linked carbohydrates, no glycolipid anchor | Mus musculus |
| glycoprotein | 30% Asp-linked carbohydrates, no glycolipid anchor | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| immunoaffinity chromatography | Rattus norvegicus |
| partial | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | from duodenum to rectum | Mus musculus | - |
| intestine | from duodenum to rectum | Rattus norvegicus | - |
| kidney | lumen of proximal tubule, juxtamedullary nephrons | Mus musculus | - |
| kidney | lumen of proximal tubule, juxtamedullary nephrons | Rattus norvegicus | - |
| additional information | tissue distribution (immuno-peroxidase staining), not in brain or spinal cord | Mus musculus | - |
| additional information | tissue distribution (immuno-peroxidase staining), not in brain or spinal cord | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| azocasein + H2O | better substrate for mouse enzyme than for rat enzyme | Mus musculus | fragments of azocasein | - |
? |  |
| azocasein + H2O | better substrate for mouse enzyme than for rat enzyme | Rattus norvegicus | fragments of azocasein | - |
? | |
| Insulin B-chain + H2O | - |
Mus musculus | Hydrolyzed insulin B-chain | - |
? | |
| Insulin B-chain + H2O | I125-iodinated | Rattus norvegicus | Hydrolyzed insulin B-chain | - |
? | |
| N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O | - |
Rattus norvegicus | N-Benzoyl-L-tyrosine + 4-aminobenzoate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| oligomer | x * 80000, SDS-PAGE, reducing conditions | Mus musculus |
| oligomer | x * 80000, SDS-PAGE, reducing conditions | Rattus norvegicus |
| oligomer | x * 90000, mouse, SDS-PAGE, reducing conditions | Mus musculus |
| oligomer | x * 90000, mouse, SDS-PAGE, reducing conditions | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | meprin A from mouse, endopeptidase-2 from rat and PPH from human are closely related enzymes of the astacin family | Mus musculus |
| More | meprin A from mouse, endopeptidase-2 from rat and PPH from human are closely related enzymes of the astacin family | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Rattus norvegicus |
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