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Literature summary for 3.4.24.18 extracted from

  • Stephenson, S.L.; Kenny, A.J.
    The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme endopeptidase-2 and by rat microvillar membranes (1988), Biochem. J., 255, 45-51.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.18

Inhibitors

Inhibitors Comment Organism Structure
additional information hippuryl-His-Leu, His-Leu, benzamidine; soybean trypsin inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
microvillus
-
 Rattus norvegicus 5902
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleavage site: Tyr-Ile Rattus norvegicus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe + Ile-His-Pro-Phe-His-Leu
-
 ?
angiotensin II + H2O poor substrate Rattus norvegicus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe
-
 ?
angiotensin III + H2O poor substrate Rattus norvegicus Arg-Val-Tyr + Ile-His-Pro-Phe
-
 ?
angiotensin III + H2O i.e. Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr-Ile Rattus norvegicus Arg-Val-Tyr + Ile-His-Pro-Phe
-
 ?
bradykinin + H2O one cleavage site: Phe-Ser (major cleavage site) Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg
-
 ?
bradykinin + H2O one cleavage site: Phe-Ser Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg
-
 ?
bradykinin + H2O minor cleavage site: Gly-Phe Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg
-
 ?
Human alpha-atrial natiuretic peptide + H2O
-
 Rattus norvegicus ?
-
 ?
Insulin B-chain + H2O I125-iodinated Rattus norvegicus Hydrolyzed insulin B-chain
-
 ?
Luliberin + H2O i.e. luteinizing-hormone releasing hormone, preferred cleavage site: Trp3-Ser4, other sites are Ser4-Tyr5 and Tyr5-Gly6 Rattus norvegicus ?
-
 ?
additional information hydrolysis occurs on carboxy side of aromatic residues Rattus norvegicus ?
-
 ?
additional information insulin, [Arg8]-vasopressin, cytochrome c, ovalbumin, serum albumin Rattus norvegicus ?
-
 ?
Substance P + H2O cleavage sites: Glu6-Phe7, Phe7-Phe8, Phe8-Gly9 Rattus norvegicus Hydrolyzed substance P
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus