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Literature summary for 3.4.24.17 extracted from

  • Ijichi, K.; Brown, G.D.; Moore, C.S.; Lee, J.P.; Winokur, P.N.; Pagarigan, R.; Snyder, E.Y.; Bongarzone, E.R.; Crocker, S.J.
    MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology (2013), Glia, 61, 765-777.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.17

Cloned(Commentary)

Cloned (Comment) Organism
gene mmp-3, quantitative real-time PCR expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme knockout mutants Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
L-asparaginyl-L-asparaginylglycyl-L-histidine
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus P28862 gene mmp-3
-
Mus musculus C57BL/6 P28862 gene mmp-3
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system age-dependent increase in the central nervous system expression of MMP-3 in Twitcher mice suffering globoid cell leukodystrophy Mus musculus
-
glial cell
-
 Mus musculus
-
globoid cell
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
microglia
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-3
-
 Mus musculus
MMP-3
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00013
-
 L-asparaginyl-L-asparaginylglycyl-L-histidine pH and temperature not specified in the publication Mus musculus

Expression

Organism Comment Expression
Mus musculus lipopolysaccharide does not induce mmp-3 mRNA expression in peripheral blood samples additional information
Mus musculus exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase-3 that mediates a morphological transformation of microglia into a multinucleated globoid cell type. But although psychosine treatment in primary purified microglial cultures moderately induces MMP-3 expression, treatment of peripheral blood or purified macrophages with equivalent concentrations of psychosine does not induce MMP-3 expression up

General Information

General Information Comment Organism
malfunction psychosine-induced globoid cell formation from microglia is prevented by either genetic ablation or chemical inhibition of enzyme MMP-3. Elevated expression of MMP-3 in globoid cell leukodystrophy or Krabbe disease, a fatal demyelinating disease, may promote microglial responses to psychosine that may represent an important pathophysiological process in this disease and its treatment Mus musculus
additional information bone marrow transplantation does not dampen elevated MMP-3 levels in globoid cell leukodystrophy-model Twitcher Mice Mus musculus
physiological function matrix metalloproteinase (MMP)-3 mediates a morphological transformation of microglia into a multinucleated globoid cell type Mus musculus