Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2S)-2-((R)-sec-butyl)-N-hydroxy-3-((4-methoxyphenyl)sulfonyl)cyclopropanecarboxamide | - |
Homo sapiens | |
(1R,3S)-N-hydroxy-2-((4-methoxyphenyl)sulfonyl)-3-((pyridin-3-yloxy)methyl)cyclopropanecarboxamide | - |
Homo sapiens | |
(1R,3S)-N-hydroxy-2-((4-methoxyphenyl)sulfonyl)-3-(5-phenylpentyl)cyclopropanecarboxamide | - |
Homo sapiens | |
1-([[4-(3,4-dimethylphenoxy)phenyl]sulfonyl]methyl)-N-hydroxy-4-(prop-2-yn-1-yl)cyclohexanecarboxamide | - |
Homo sapiens | |
1-acetyl-N-hydroxy-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
1-cyclopropyl-N-hydroxy-4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
1-cyclopropyl-N-hydroxy-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
2-[(biphenyl-4-ylsulfonyl)[2-(hydroxyamino)-2-oxoethyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | - |
Homo sapiens | |
2-[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | - |
Homo sapiens | |
2-[[2-(hydroxyamino)-2-oxoethyl][(4-phenoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | - |
Homo sapiens | |
3-(hydroxycarbamoyl)-1-[(4-phenoxybenzoyl)amino]pentyl 2,2-dimethylpropanoate | - |
Homo sapiens | |
3-ethyl-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide | - |
Homo sapiens | |
3-[(benzyloxy)methyl]-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
3-[(benzylsulfanyl)methyl]-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[(2S)-1-hydroxy-5-(hydroxyamino)-5-oxopentan-2-yl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[(2S)-2-hydroxy-4-(hydroxyamino)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[(2S)-4-(hydroxyamino)-2-(methoxymethoxy)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[(2S)-5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[(3R)-3-[(benzyloxy)methyl]-4-(hydroxyamino)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[(3S)-3-hydroxy-4-(hydroxyamino)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[3-(hydroxycarbamoyl)-6-phenylhexyl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[3-benzyl-4-(hydroxyamino)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-(1-benzofuran-2-yl)-N-[4-(hydroxyamino)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-(hydroxyamino)-3-methyl-4-oxo-1-[(4-phenoxybenzoyl)amino]butyl 2,2-dimethylpropanoate | - |
Homo sapiens | |
4-([[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | - |
Homo sapiens | |
4-([[4-(biphenyl-4-yloxy)phenyl]sulfonyl]methyl)-N-hydroxy-1-(2-phenylethyl)piperidine-4-carboxamide | - |
Homo sapiens | |
4-([[4-(biphenyl-4-yloxy)phenyl]sulfonyl]methyl)-N-hydroxypiperidine-4-carboxamide | - |
Homo sapiens | |
4-[(E)-2-(4-chlorophenyl)ethenyl]-N-[4-(hydroxyamino)-4-oxobutyl]benzamide | - |
Homo sapiens | |
4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-N-hydroxytetrahydro-2H-pyran-4-carboxamide | - |
Homo sapiens | |
benzyl [3-[(biphenyl-4-ylsulfonyl)(propan-2-yloxy)amino]-4-(hydroxyamino)-4-oxobutyl]carbamate | - |
Homo sapiens | |
additional information | ligand binding, inhibitory potencies, 3D-QSAR modelling, and crystal structures, overview. Usage of multitemplate alignment method for the development of a 3D QSAR model | Homo sapiens | |
N-(biphenyl-4-ylsulfonyl)-N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]glycine | - |
Homo sapiens | |
N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-1-(2-methoxyethyl)-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-1-methyl-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethyl-3-[[(2-phenylethyl)sulfanyl]methyl]prolinamide | - |
Homo sapiens | |
N-hydroxy-1-[(methylsulfonyl)oxy]-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-1-[[(4-phenoxyphenyl)sulfonyl]methyl]-4-(prop-2-yn-1-yl)cyclohexanecarboxamide | - |
Homo sapiens | |
N-hydroxy-3-(hydroxymethyl)-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
N-hydroxy-3-[(1R)-1-hydroxy-2-(phenylsulfanyl)ethyl]-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
N-hydroxy-3-[(1S)-1-hydroxy-2-(phenylsulfanyl)ethyl]-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
N-hydroxy-3-[[(4-methoxybenzyl)sulfanyl]methyl]-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | - |
Homo sapiens | |
N-hydroxy-4-[(4-phenoxyphenyl)sulfonyl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-4-[[(4-phenoxyphenyl)sulfonyl]methyl]-1-(2-phenylethyl)piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]-1-(prop-2-en-1-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-methylpropyl)phenyl-D-methioninamide | - |
Homo sapiens | |
N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-methoxyphenyl)sulfonyl]glycine | - |
Homo sapiens | |
N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-phenoxyphenyl)sulfonyl]glycine | - |
Homo sapiens | |
N-[1-(ethoxymethoxy)-3-(hydroxycarbamoyl)pentyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[1-(ethoxymethoxy)-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[1-hydroxy-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[3-(hydroxycarbamoyl)-1-[(2-methoxyethoxy)methoxy]pentyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxyamino)-1-[(2-methoxyethoxy)methoxy]-3-methyl-4-oxobutyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxyamino)-4-oxobutyl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxyamino)-4-oxobutyl]-4-[(E)-2-(4-hydroxyphenyl)ethenyl]benzamide | - |
Homo sapiens | |
N-[4-(hydroxyamino)-4-oxobutyl]-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzamide | - |
Homo sapiens | |
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-5,5-dimethylhexan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-7,7-dimethyl-6-oxooctan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)hept-6-en-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)heptan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)hexan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)octan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[4-hydroxy-5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-(naphthalen-1-ylmethyl)-5-oxopentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(1l4-thiopyran-1-yl)pentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-2-ylmethyl)pentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-3-ylmethyl)pentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-4-ylmethyl)pentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide | - |
Homo sapiens | |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide | - |
Homo sapiens | |
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)valinamide | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 + H2O | fluorogenic substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000012 | - |
pH 7.5, 25°C | Homo sapiens | N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-2-ylmethyl)pentan-2-yl]-4-phenoxybenzamide | |
0.0000061 | - |
pH 7.5, 25°C | Homo sapiens | 2-[[2-(hydroxyamino)-2-oxoethyl][(4-phenoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | |
0.0000067 | - |
pH 7.5, 25°C | Homo sapiens | N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-phenoxyphenyl)sulfonyl]glycine | |
0.00002 | - |
pH 7.5, 25°C | Homo sapiens | N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-7,7-dimethyl-6-oxooctan-2-yl]-4-phenoxybenzamide | |
0.0000372 | - |
pH 7.5, 25°C | Homo sapiens | N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide | |
0.000127 | - |
pH 7.5, 25°C | Homo sapiens | N-(biphenyl-4-ylsulfonyl)-N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]glycine | |
0.00014 | - |
pH 7.5, 25°C | Homo sapiens | 2-[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | |
0.000163 | - |
pH 7.5, 25°C | Homo sapiens | N-hydroxy-3-(hydroxymethyl)-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide | |
0.000182 | - |
pH 7.5, 25°C | Homo sapiens | N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-methoxyphenyl)sulfonyl]glycine | |
0.00043 | - |
pH 7.5, 25°C | Homo sapiens | 2-[(biphenyl-4-ylsulfonyl)[2-(hydroxyamino)-2-oxoethyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | |
0.00138 | - |
pH 7.5, 25°C | Homo sapiens | N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide |