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Literature summary for 3.4.24.17 extracted from

  • Tuccinardi, T.; Ortore, G.; Santos, M.A.; Marques, S.M.; Nuti, E.; Rossello, A.; Martinelli, A.
    Multitemplate alignment method for the development of a reliable 3D-QSAR model for the analysis of MMP3 inhibitors (2009), J. Chem. Inf. Model., 49, 1715-1724.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1R,2S)-2-((R)-sec-butyl)-N-hydroxy-3-((4-methoxyphenyl)sulfonyl)cyclopropanecarboxamide
-
Homo sapiens
(1R,3S)-N-hydroxy-2-((4-methoxyphenyl)sulfonyl)-3-((pyridin-3-yloxy)methyl)cyclopropanecarboxamide
-
Homo sapiens
(1R,3S)-N-hydroxy-2-((4-methoxyphenyl)sulfonyl)-3-(5-phenylpentyl)cyclopropanecarboxamide
-
Homo sapiens
1-([[4-(3,4-dimethylphenoxy)phenyl]sulfonyl]methyl)-N-hydroxy-4-(prop-2-yn-1-yl)cyclohexanecarboxamide
-
Homo sapiens
1-acetyl-N-hydroxy-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
1-cyclopropyl-N-hydroxy-4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
1-cyclopropyl-N-hydroxy-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
2-[(biphenyl-4-ylsulfonyl)[2-(hydroxyamino)-2-oxoethyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
-
Homo sapiens
2-[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
-
Homo sapiens
2-[[2-(hydroxyamino)-2-oxoethyl][(4-phenoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
-
Homo sapiens
3-(hydroxycarbamoyl)-1-[(4-phenoxybenzoyl)amino]pentyl 2,2-dimethylpropanoate
-
Homo sapiens
3-ethyl-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide
-
Homo sapiens
3-[(benzyloxy)methyl]-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
3-[(benzylsulfanyl)methyl]-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[(2S)-1-hydroxy-5-(hydroxyamino)-5-oxopentan-2-yl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[(2S)-2-hydroxy-4-(hydroxyamino)-4-oxobutyl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[(2S)-4-(hydroxyamino)-2-(methoxymethoxy)-4-oxobutyl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[(2S)-5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[(3R)-3-[(benzyloxy)methyl]-4-(hydroxyamino)-4-oxobutyl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[(3S)-3-hydroxy-4-(hydroxyamino)-4-oxobutyl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[3-(hydroxycarbamoyl)-6-phenylhexyl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[3-benzyl-4-(hydroxyamino)-4-oxobutyl]benzamide
-
Homo sapiens
4-(1-benzofuran-2-yl)-N-[4-(hydroxyamino)-4-oxobutyl]benzamide
-
Homo sapiens
4-(hydroxyamino)-3-methyl-4-oxo-1-[(4-phenoxybenzoyl)amino]butyl 2,2-dimethylpropanoate
-
Homo sapiens
4-([[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
-
Homo sapiens
4-([[4-(biphenyl-4-yloxy)phenyl]sulfonyl]methyl)-N-hydroxy-1-(2-phenylethyl)piperidine-4-carboxamide
-
Homo sapiens
4-([[4-(biphenyl-4-yloxy)phenyl]sulfonyl]methyl)-N-hydroxypiperidine-4-carboxamide
-
Homo sapiens
4-[(E)-2-(4-chlorophenyl)ethenyl]-N-[4-(hydroxyamino)-4-oxobutyl]benzamide
-
Homo sapiens
4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-N-hydroxytetrahydro-2H-pyran-4-carboxamide
-
Homo sapiens
benzyl [3-[(biphenyl-4-ylsulfonyl)(propan-2-yloxy)amino]-4-(hydroxyamino)-4-oxobutyl]carbamate
-
Homo sapiens
additional information ligand binding, inhibitory potencies, 3D-QSAR modelling, and crystal structures, overview. Usage of multitemplate alignment method for the development of a 3D QSAR model Homo sapiens
N-(biphenyl-4-ylsulfonyl)-N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]glycine
-
Homo sapiens
N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-1-(2-methoxyethyl)-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-1-methyl-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethyl-3-[[(2-phenylethyl)sulfanyl]methyl]prolinamide
-
Homo sapiens
N-hydroxy-1-[(methylsulfonyl)oxy]-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-1-[[(4-phenoxyphenyl)sulfonyl]methyl]-4-(prop-2-yn-1-yl)cyclohexanecarboxamide
-
Homo sapiens
N-hydroxy-3-(hydroxymethyl)-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
N-hydroxy-3-[(1R)-1-hydroxy-2-(phenylsulfanyl)ethyl]-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
N-hydroxy-3-[(1S)-1-hydroxy-2-(phenylsulfanyl)ethyl]-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
N-hydroxy-3-[[(4-methoxybenzyl)sulfanyl]methyl]-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
-
Homo sapiens
N-hydroxy-4-[(4-phenoxyphenyl)sulfonyl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-4-[(4-phenoxyphenyl)sulfonyl]piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-4-[[(4-phenoxyphenyl)sulfonyl]methyl]-1-(2-phenylethyl)piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-4-[[4-(phenylsulfanyl)phenyl]sulfonyl]-1-(prop-2-en-1-yl)piperidine-4-carboxamide
-
Homo sapiens
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-methylpropyl)phenyl-D-methioninamide
-
Homo sapiens
N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-methoxyphenyl)sulfonyl]glycine
-
Homo sapiens
N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-phenoxyphenyl)sulfonyl]glycine
-
Homo sapiens
N-[1-(ethoxymethoxy)-3-(hydroxycarbamoyl)pentyl]-4-phenoxybenzamide
-
Homo sapiens
N-[1-(ethoxymethoxy)-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
-
Homo sapiens
N-[1-hydroxy-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
-
Homo sapiens
N-[3-(hydroxycarbamoyl)-1-[(2-methoxyethoxy)methoxy]pentyl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxyamino)-1-[(2-methoxyethoxy)methoxy]-3-methyl-4-oxobutyl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxyamino)-4-oxobutyl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxyamino)-4-oxobutyl]-4-[(E)-2-(4-hydroxyphenyl)ethenyl]benzamide
-
Homo sapiens
N-[4-(hydroxyamino)-4-oxobutyl]-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzamide
-
Homo sapiens
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-5,5-dimethylhexan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-7,7-dimethyl-6-oxooctan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)hept-6-en-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)heptan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)hexan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)octan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[4-hydroxy-5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-(naphthalen-1-ylmethyl)-5-oxopentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(1l4-thiopyran-1-yl)pentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-2-ylmethyl)pentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-3-ylmethyl)pentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-4-ylmethyl)pentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide
-
Homo sapiens
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)glycinamide
-
Homo sapiens
N2-(biphenyl-4-ylsulfonyl)-N-hydroxy-N2-(propan-2-yloxy)valinamide
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 + H2O fluorogenic substrate Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MMP3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000012
-
pH 7.5, 25°C Homo sapiens N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-2-ylmethyl)pentan-2-yl]-4-phenoxybenzamide
0.0000061
-
pH 7.5, 25°C Homo sapiens 2-[[2-(hydroxyamino)-2-oxoethyl][(4-phenoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
0.0000067
-
pH 7.5, 25°C Homo sapiens N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-phenoxyphenyl)sulfonyl]glycine
0.00002
-
pH 7.5, 25°C Homo sapiens N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-7,7-dimethyl-6-oxooctan-2-yl]-4-phenoxybenzamide
0.0000372
-
pH 7.5, 25°C Homo sapiens N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide
0.000127
-
pH 7.5, 25°C Homo sapiens N-(biphenyl-4-ylsulfonyl)-N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]glycine
0.00014
-
pH 7.5, 25°C Homo sapiens 2-[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
0.000163
-
pH 7.5, 25°C Homo sapiens N-hydroxy-3-(hydroxymethyl)-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide
0.000182
-
pH 7.5, 25°C Homo sapiens N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-methoxyphenyl)sulfonyl]glycine
0.00043
-
pH 7.5, 25°C Homo sapiens 2-[(biphenyl-4-ylsulfonyl)[2-(hydroxyamino)-2-oxoethyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
0.00138
-
pH 7.5, 25°C Homo sapiens N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide