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Literature summary for 3.4.24.17 extracted from

  • Phromnoi, K.; Yodkeeree, S.; Anuchapreeda, S.; Limtrakul, P.
    Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids (2009), Acta Pharmacol. Sin., 30, 1169-1176.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.17

Inhibitors

Inhibitors Comment Organism Structure
daidzein
-
 Homo sapiens
genistein
-
 Homo sapiens
genistin
-
 Homo sapiens
kaempferol
-
 Homo sapiens
additional information the flavonols quercetin and kaempferol have higher anti-invasion potency and higher MMP-3 inhibitory activity than isoflavones genistein, genistin and daidzein, but neither flavonols nor isoflavones have any effect on MMP-3 secretion Homo sapiens
quercetin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular MMP-3 is secreted Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell a human invasive breast carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O casein zymography assay Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 3
-
 Homo sapiens
MMP-3
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction MMP-3 is involved in breast cancer cell invasiveness Homo sapiens