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Literature summary for 3.4.24.17 extracted from

  • McCawley, L.J.; Crawford, H.C.; King, L.E.; Mudgett, J.; Matrisian, L.M.
    A protective role for matrix metalloproteinase-3 in squamous cell carcinoma (2004), Cancer Res., 64, 6965-6972.
    View publication on PubMed
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Application

Application Comment Organism
medicine wild-type and enzyme null mutant animals, chemical carcinogenesis by 1-methyl-3-nitro-1-nitroso-guanidine or by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate. No difference in tumor onset or incidence between wild-type and enzyme null mutant animal, but tumors originating on mutant mice have enhanced initial tumor growth coupled with with an elevated proliferative index and reduced vasculature density Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is expressed as a protective response and plays an important role in host defense during squamous cell carcinoma tumorigenesis ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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 wild-type and enzyme-null mutant animal
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is expressed as a protective response and plays an important role in host defense during squamous cell carcinoma tumorigenesis Mus musculus ?
-
 ?