Literature summary for 3.4.24.17 extracted from

Huet, E.; Cauchard, J.; Berton, A.; Robinet, A.; Decarme, M.; Hornebeck, W.; Bellon, G.
Inhibition of plasmin-mediated prostromelysin-1 activation by interaction of long chain unsaturated fatty acids with kringle 5. [Erratum to document cited in CA140:297422] (2004), Biochem. Pharmacol., 67, 1011.

No PubMed abstract available

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Application

Application	Comment	Organism
medicine	development of natural pharmacological inhibitors of enzyme: Proenzyme is proteolytically activated by plasmin. C18 unsaturated fatty acids are inhibitory, with elaidic acid totally abolishing the activation. Inhibitory effect result from binding of unsaturated fatty acids to kringle 5	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	proenzyme is proteolytically activated by plasmin. C18 unsaturated fatty acids are inhibitory, with elaidic acid totally abolishing the activation. Inhibitory effect result from binding of unsaturated fatty acids to kringle 5	Homo sapiens

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Release 2023.1 (January 2023)