Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.16 extracted from

  • Jeske, N.A.; Berg, K.A.; Cousins, J.C.; Ferro, E.S.; Clarke, W.P.; Glucksman, M.J.; Roberts, J.L.
    Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia (2006), J. Neurochem., 97, 13-21.
    View publication on PubMed
Search for more literature for 3.4.24.16

Application

Application Comment Organism
additional information EP12.16 modulates intracellular, peptidergic signaling cascades through the type-2 BK receptor in physiologically relevant nociceptive system Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
N-(1(R,S)-carboxy-3-phenylpropyl)-Ala-Ala-Tyr-p-aminobenzoate inhibits EP24.16 resulting in a 1000fold increase in type-2 BK receptor sensitivity to bradykinin as measured by inositol phosphate accumulation Rattus norvegicus
Pro-Ile causes a 100fold leftward shift in the concentration response curve for bradykinin-induced inositol phosphate generation, moreover leads to a potentiation of bradykinin-induced reduction in protein kinase B activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
trigeminal ganglion
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ep24.16
-
 Rattus norvegicus