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Literature summary for 3.4.24.16 extracted from

  • Checler, F.; Vincent, J.P.; Kitabgi, P.
    Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes (1986), J. Biol. Chem., 261, 11274-11281.
    View publication on PubMed
Search for more literature for 3.4.24.16

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 1 mM, 95% inhibition Rattus norvegicus
alpha-melanotrophin-stimulating hormone weak Rattus norvegicus
angiotensin I
-
 Rattus norvegicus
bombesin weak Rattus norvegicus
carboxyphenylethyl-Ala-Ala-Phe-4-aminobenzoate 0.001 mM, 30% inhibition Rattus norvegicus
EDTA 1 mM, 51% inhibition Rattus norvegicus
Neuromedin N
-
 Rattus norvegicus
neurotensin(9-13) the shortest neurotensin partial sequence that is able to fully inhibit neurotensin degradation Rattus norvegicus
Somatostatin weak Rattus norvegicus
Substance P weak Rattus norvegicus
Tuftsin weak Rattus norvegicus
Xenopsin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
 neurotensin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane synaptic Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0226
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
neurotensin + H2O
-
 Rattus norvegicus ?
-
 ?
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu + H2O i.e. neurotensin Rattus norvegicus pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro + Tyr-Ile-Leu
-
 ?