Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.15 extracted from

  • Simoes, P.S.; Visniauskas, B.; Perosa, S.R.; Yacubian, E.M.; Centeno, R.; Canzian, M.; Lopes-Cendes, I.; Maurer Morelli, C.V.; Carrete, H.; Cavalheiro, E.A.; Tufik, S.; Chagas, J.R.; Mazzacoratti, M.d.a..G.
    Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE) (2014), Epilepsia, 55, 754-762.
    View publication on PubMed
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Aib-Tyr-p-aminobenzoate specific inhibitor JA-2 Rattus norvegicus
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-4-aminobenzoate specific inhibitor JA-2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P52888
-
-
Rattus norvegicus P24155
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain
-
 Homo sapiens
-
hippocampus enzyme immunostaining in the sclerotic hippocampus Rattus norvegicus
-
hippocampus enzyme immunostaining in the sclerotic hippocampus Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-GFDPFRQ-EDDnp + H2O
-
 Rattus norvegicus ?
-
 ?
Abz-GFDPFRQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TOP
-
 Rattus norvegicus
TOP
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus expression and activity of thimet oligopeptidase are increased in the hippocampus of in rats during the acute phase of pilocarpine-induced epilepsy model up
Homo sapiens expression and activity of thimet oligopeptidase are increased in the hippocampus of subjects with temporal lobe epilepsy up

General Information

General Information Comment Organism
additional information expression and activity of thimet oligopeptidase are increased in the hippocampus in rats during the acute phase of pilocarpine-induced epilepsy model, but not in the silent phase. In addition, decreased enzyme distribution is also visualized by immunohistochemistry. These alterations can be related to a failure in the mechanisms involved in clearance of inflammatory peptides in the hippocampus, suggesting an accumulation of potentially harmful substances in nervous tissue such as amyloid beta, bradykinin, and antigenic peptides Rattus norvegicus
additional information expression and activity of thimet oligopeptidase are increased in the hippocampus in the chronic phase of subjects with temporal lobe epilepsy, but not in the silent phase. In addition, decreased enzyme distribution is also visualized by immunohistochemistry. These alterations can be related to a failure in the mechanisms involved in clearance of inflammatory peptides in the hippocampus, suggesting an accumulation of potentially harmful substances in nervous tissue such as amyloid beta, bradykinin, and antigenic peptides Homo sapiens