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Literature summary for 3.4.24.15 extracted from

  • Guinan, A.F.; Rochfort, K.D.; Fitzpatrick, P.A.; Walsh, T.G.; Pierotti, A.R.; Phelan, S.; Murphy, R.P.; Cummins, P.M.
    Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels (2013), Cardiovasc. Res., 99, 545-554.
    View publication on PubMed
Search for more literature for 3.4.24.15

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis by quantitative real-time PCR Homo sapiens
expression analysis by quantitative real-time PCR Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-
soluble
-
 Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus Q1JPJ8
-
-
Homo sapiens P52888
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell
-
 Homo sapiens
-
aortic endothelial cell
-
 Bos taurus
-
additional information enzyme expression analysis by quantitative real-time PCR Homo sapiens
-
additional information enzyme expression analysis by quantitative real-time PCR Bos taurus
-
vascular endothelial cell
-
 Homo sapiens
-
vascular endothelial cell
-
 Bos taurus
-

Synonyms

Synonyms Comment Organism
TOP
-
 Homo sapiens
TOP
-
 Bos taurus

Expression

Organism Comment Expression
Homo sapiens enzyme mRNA and protein are consistently up-regulated by shear stress, which can be completely prevented by pre-treatment of cells with either N-acetylcysteine, superoxide dismutase, or catalase, confirming ROS involvement up
Bos taurus enzyme mRNA and protein are consistently up-regulated by shear stress, which can be completely prevented by pre-treatment of cells with either N-acetylcysteine, superoxide dismutase, or catalase, confirming ROS involvement up

General Information

General Information Comment Organism
metabolism relationship between enzyme expression and laminar shear stress, a haemodynamic force associated with endothelium-mediated vascular homeostasis, shear stress is a positive regulator of thimet oligopeptidase in vascular endothelial cells activating the TOP promoter. Shear stress-dependent induction of the enzyme may lower MHC1 expression Homo sapiens
metabolism relationship between enzyme expression and laminar shear stress, a haemodynamic force associated with endothelium-mediated vascular homeostasis, shear stress is a positive regulator of thimet oligopeptidase in vascular endothelial cells activating the TOP promoter. Shear stress-dependent induction of the enzyme may lower MHC1 expression Bos taurus