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Literature summary for 3.4.24.15 extracted from

  • Wu, T.J.; Pierotti, A.R.; Jakubowski, M.; Sheward, W.J.; Glucksman, M.J.; Smith, A.I.; King, J.C.; Fink, G.; Roberts, J.L.
    Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge (1997), J. Neuroendocrinol., 9, 813-822.
    View publication on PubMed
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-pAB i.e. cFP-AAF-pAB, a transition state analogue inhibitor specific for EP24.15 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloendopeptidase Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly + H2O Rattus norvegicus gonadotropin-releasing hormone, the enzyme degrades gonadotropin-releasing hormone, GnRH, by cleaving the central Tyr5-Gly6 bond pyroGlu-His-Trp-Ser-Tyr + Gly-Leu-Arg-Pro-Gly
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood hypophysial portal blood Rattus norvegicus
-
central nervous system
-
 Rattus norvegicus
-
additional information presence of EP24.15 in the perivascular space of the median eminence and secretion into portal blood Rattus norvegicus
-
pituitary gland
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly + H2O gonadotropin-releasing hormone, the enzyme degrades gonadotropin-releasing hormone, GnRH, by cleaving the central Tyr5-Gly6 bond Rattus norvegicus pyroGlu-His-Trp-Ser-Tyr + Gly-Leu-Arg-Pro-Gly
-
 ?

Synonyms

Synonyms Comment Organism
endopeptidase EC 3.4.24.15
-
 Rattus norvegicus
EP24.15
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition of EP24.15 activity with a specific inhibitor augments the steroid-induced luteinizing hormone increase in ovariectomized rats Rattus norvegicus
physiological function EP24.15 can modulate the concentrations of gonadotropin-releasing hormone within the hypothalamo-hypophysial portal blood and thereby plays a physiological role in reproduction Rattus norvegicus