Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.15 extracted from

  • Crack, P.J.; Wu, T.J.; Cummins, P.M.; Ferro, E.S.; Tullai, J.W.; Glucksman, M.J.; Roberts, J.L.
    The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane (1999), Brain Res., 835, 113-124.
    View publication on PubMed
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
N-[1-(RS)-carboxyl-2-phenylethyl]-Ala-Ala-Phe-4-amino-benzoate i.e. cFP-AAF-pAB, an active site-directed inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information determination of subcellular localization, fractionation and immunohistochemic analysis, overview Mus musculus
-
-
plasma membrane EP24.15 is associated with the extracellular surface of the cell discernable from the secreted enzyme Mus musculus 5886
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell a pituitary tumour cell line Mus musculus
-
brain
-
 Mus musculus
-
gonad
-
 Mus musculus
-
pituitary gland
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-2,4-dinitrophenyl + H2O fluorogenic substrate Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
endopeptidase EC 3.4.24.15
-
 Mus musculus
EP24.15
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function EP24.15 is a soluble, neuropeptide-degrading metalloenzyme and plays a role in the degradation of neuropeptides acting at the external cell surface and in the physiological metabolism of neuropeptides Mus musculus