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Literature summary for 3.4.24.15 extracted from
- Inactivation of neurotensin and neuromedin N by Zn metallopeptidases (2006), Peptides, 27, 2515-2522.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloned from testis and brain | Mus musculus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure determination | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cPP-Ala-Ala-Tyr-pAB | - |
Canis lupus familiaris |  |
| cPP-Ala-Ala-Tyr-pAB | - |
Homo sapiens | |
| cPP-Ala-Ala-Tyr-pAB | - |
Mus musculus | |
| JMV390-1 | - |
Canis lupus familiaris | |
| JMV390-1 | - |
Homo sapiens | |
| JMV390-1 | - |
Mus musculus | |
| o-phenanthroline | strong inhibition | Canis lupus familiaris | |
| o-phenanthroline | strong inhibition | Homo sapiens | |
| o-phenanthroline | strong inhibition | Mus musculus | |
| phosphodiepryl 08 | - |
Canis lupus familiaris | |
| phosphodiepryl 08 | - |
Homo sapiens | |
| phosphodiepryl 08 | - |
Mus musculus | |
| phosphodiepryl 21 | - |
Canis lupus familiaris | |
| phosphodiepryl 21 | - |
Homo sapiens | |
| phosphodiepryl 21 | - |
Mus musculus | |
| phosphodiepryl 33 | - |
Canis lupus familiaris | |
| phosphodiepryl 33 | - |
Homo sapiens | |
| phosphodiepryl 33 | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | synaptic and fundus membranes in brain | Mus musculus | 16020 | - |
| membrane | synaptic and smooth muscle cell membranes in brain | Canis lupus familiaris | 16020 | - |
| additional information | wide distribution | Mus musculus | - |
- |
| additional information | wide distribution | Homo sapiens | - |
- |
| additional information | wide distribution | Canis lupus familiaris | - |
- |
| synapse | - |
Mus musculus | 45202 | - |
| synapse | synaptosomal fraction | Canis lupus familiaris | 45202 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | metalloendopeptidase containing a HEXXHmotif | Mus musculus | |
| Zn2+ | metalloendopeptidase containing a HEXXHmotif | Homo sapiens | |
| Zn2+ | metalloendopeptidase containing a HEXXHmotif | Canis lupus familiaris | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 78000 | - |
x * 78000, three-dimensional structure, comparison to EC 3.4.24.16 | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is active in inactivation of neuropeptides, biological relevance, overview | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is active in inactivation of neuropeptides, biological relevance, overview | ? | - |
? | |
| additional information | Canis lupus familiaris | the enzyme is active in inactivation of neuropeptides, biological relevance, overview | ? | - |
? | |
| neuromedin N + H2O | Mus musculus | degradation | ? | - |
? | |
| neuromedin N + H2O | Homo sapiens | degradation | ? | - |
? | |
| neuromedin N + H2O | Canis lupus familiaris | degradation | ? | - |
? | |
| neurotensin + H2O | Mus musculus | degradation | ? | - |
? | |
| neurotensin + H2O | Homo sapiens | degradation | ? | - |
? | |
| neurotensin + H2O | Canis lupus familiaris | degradation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from brain | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Canis lupus familiaris | - |
| HT-29 cell | colon cancer cell line | Homo sapiens | - |
| ileum | longitudinal smooth muscle membranes and circular smooth muscle membranes | Canis lupus familiaris | - |
| additional information | wide distribution | Mus musculus | - |
| additional information | wide distribution | Homo sapiens | - |
| additional information | wide distribution | Canis lupus familiaris | - |
| N1E-115 cell | neuroblastoma cells | Mus musculus | - |
| neuron | primary culture | Mus musculus | - |
| smooth muscle cell | ileum, longitudinal and circular | Canis lupus familiaris | - |
| testis | high enzyme content | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
| additional information | the enzyme is active in inactivation of neuropeptides, biological relevance, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme is active in inactivation of neuropeptides, biological relevance, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is active in inactivation of neuropeptides, biological relevance, overview | Canis lupus familiaris | ? | - |
? | |
| neuromedin N + H2O | degradation | Mus musculus | ? | - |
? | |
| neuromedin N + H2O | degradation | Homo sapiens | ? | - |
? | |
| neuromedin N + H2O | degradation | Canis lupus familiaris | ? | - |
? | |
| neuromedin N + H2O | i.e. H-Lys-Ile-Pro-Tyr-Ile-Leu-OH | Mus musculus | ? | - |
? | |
| neuromedin N + H2O | i.e. H-Lys-Ile-Pro-Tyr-Ile-Leu-OH | Homo sapiens | ? | - |
? | |
| neuromedin N + H2O | i.e. H-Lys-Ile-Pro-Tyr-Ile-Leu-OH | Canis lupus familiaris | ? | - |
? | |
| neurotensin + H2O | degradation | Mus musculus | ? | - |
? | |
| neurotensin + H2O | degradation | Homo sapiens | ? | - |
? | |
| neurotensin + H2O | degradation | Canis lupus familiaris | ? | - |
? | |
| neurotensin + H2O | cleavage of the Arg8-Arg9 bond | Mus musculus | ? | - |
? | |
| neurotensin + H2O | cleavage of the Arg8-Arg9 bond | Homo sapiens | ? | - |
? | |
| neurotensin + H2O | cleavage of the Arg8-Arg9 bond | Canis lupus familiaris | ? | - |
? | |
| somatostatin + H2O | - |
Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 78000, three-dimensional structure, comparison to EC 3.4.24.16 | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EP 24.15 | - |
Mus musculus |
| EP 24.15 | - |
Homo sapiens |
| EP 24.15 | - |
Canis lupus familiaris |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Mus musculus | |
| additional information | - |
additional information | - |
Homo sapiens | |
| additional information | - |
additional information | - |
Canis lupus familiaris |
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