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Literature summary for 3.4.24.15 extracted from
- Thimet oligopeptidase (EC 3.4.24.15) activates CPI-0004Na, an extracellularly tumour-activated prodrug of doxorubicin (2006), Eur. J. Cancer, 42, 3049-3056.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| thiol | stimulation | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme is involved in extracellular activation of CPI-0004Na prodrug | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 72000 | - |
x * 72000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CPI-0004Na + H2O | tetrapeptidic prodrug of doxorubicin | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 72000, SDS-PAGE | Homo sapiens |
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