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Literature summary for 3.4.24.15 extracted from

  • Machado, M.F.; Cunha, F.M.; Berti, D.A.; Heimann, A.S.; Klitzke, C.F.; Rioli, V.; Oliveira, V.; Ferro, E.S.
    Substrate phosphorylation affects degradation and interaction to endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme (2006), Biochem. Biophys. Res. Commun., 339, 520-525.
    View publication on PubMed
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
L-phospho-Thr-Leu-Arg-Thr-Lys-Leu comparison with inhibitory effect on EC3.4.24.16 and angiotensin-converting enzyme Sus scrofa
LTLRTKL comparison with inhibitory effect on EC3.4.24.16 and angiotensin-converting enzyme Sus scrofa
LVVYPW-phenylThr-Gln-Arg-Tyr comparison with inhibitory effect on EC3.4.24.16 and angiotensin-converting enzyme Sus scrofa
LVVYPWTQRY comparison with inhibitory effect on EC3.4.24.16 and angiotensin-converting enzyme Sus scrofa
additional information phosphorylation of substrates reduces catalytic activity, phosphorylation of competitive inhibitors only alters their Ki-values Sus scrofa
VVYPW-phenylThr-Gln-Arg-Tyr comparison with inhibitory effect on EC3.4.24.16 and angiotensin-converting enzyme Sus scrofa
VVYPWTQRY comparison with inhibitory effect on EC3.4.24.16 and angiotensin-converting enzyme Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-GFSHFRQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Sus scrofa 2-aminobenzoyl-GFSH + FRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
LTLRTKL + H2O at 91% of the rate with RPPGF-SP-FR Sus scrofa LTLR + Thr + Lys-Leu
-
 ?
additional information phosphorylation of substrates reduces catalytic activity, phosphorylation of competitive inhibitors only alters their Ki-values Sus scrofa ?
-
 ?
pTLRTKL + H2O at 10% of the rate with RPPGF-SP-FR Sus scrofa phospho-Thr-Leu-Arg + L-tyrosine + Lys-Leu
-
 ?
RPPGFSPFR + H2O
-
 Sus scrofa RPPGF + Ser-Pro + Phe-Arg
-
 ?
VVYPW-TQ-RY-KL + H2O at 9% of the rate with RPPGF-SP-FR Sus scrofa VVYPW + Thr-Gln + Arg-Tyr + Lys-Leu
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
 LVVYPW-phenylThr-Gln-Arg-Tyr pH 8.0, 37°C Sus scrofa
0.0014
-
 VVYPWTQRY pH 8.0, 37°C Sus scrofa
0.0021
-
 LVVYPWTQRY pH 8.0, 37°C Sus scrofa
0.0026
-
 LTLRTKL pH 8.0, 37°C Sus scrofa
0.0046
-
 VVYPW-phenylThr-Gln-Arg-Tyr pH 8.0, 37°C Sus scrofa
0.0063
-
 L-phospho-Thr-Leu-Arg-Thr-Lys-Leu pH 8.0, 37°C Sus scrofa