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Literature summary for 3.4.24.15 extracted from

  • Lew, R.A.; Boulos, E.; Stewart, K.M.; Perlmutter, P.; Harte, M.F.; Bond, S.; Reeve, S.B.; Norman, M.U.; Lew, M.J.; Aguilar, M.I.; Smith, I.
    Substrate analogues incorporating b-amino acids: potential application for peptidase inhibition (2001), FASEB J., 15, 1664-1666.
    View publication on PubMed
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
(3-aminopropanoyl)-Pro-Pro-Gly-Phe-(3-aminopropanoic acid)-Pro-Phe-Arg no degradation by EC 3.4.24.15 Rattus norvegicus
Arg-Pro-Ala-Gly-Phe-(3-aminopropanoyl)-Pro-Phe-Arg no degradation by EC 3.4.24.15 Rattus norvegicus
Arg-Pro-Pro-Ala-Phe-(3-aminopropanoyl)-Pro-Phe-Arg low degradation by EC 3.4.24.15 Rattus norvegicus
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg IC50: 0.007 mM, degradation by EC 3.4.24.15 Rattus norvegicus
RPPG-((3R)-3-amino-4-phenylbutanoic acid)-SPFR IC50: 0.012 mM; no degradation by EC 3.4.24.15 Rattus norvegicus
RPPG-((3S)-3-amino-4-phenylbutanoic acid)-SPFR IC50: 0.02 mM; no degradation by EC 3.4.24.15 Rattus norvegicus
RPPG-(2-aminomethyl-3-phenylpropionic acid)-SPFR no degradation by EC 3.4.24.15 Rattus norvegicus
RPPGF-((3R)-3-amino-4-hydroxybutanoic acid)-PFR no degradation by EC 3.4.24.15 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumaryl-4-acetyl-Pro-Leu-Gly-D-Lys-(2,4-dinitrophenyl) + H2O
-
 Rattus norvegicus ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
 IC50: 0.007 mM, degradation by EC 3.4.24.15 Rattus norvegicus Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
0.012
-
 IC50: 0.012 mM Rattus norvegicus RPPG-((3R)-3-amino-4-phenylbutanoic acid)-SPFR
0.02
-
 IC50: 0.02 mM Rattus norvegicus RPPG-((3S)-3-amino-4-phenylbutanoic acid)-SPFR