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Literature summary for 3.4.24.15 extracted from

  • Shrimpton, C.N.; Abbenante, G.; Lew, R.A.; Smith, A.I.
    Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15 (2000), Biochem. J., 345, 351-356.
No PubMed abstract available
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-p-aminobenzoate the inhibitor is degraded at the Ala-Tyr bond, thus severely limiting its utility in vivo Rattus norvegicus
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(alpha-aminoisobutyryl)-Tyr-p-aminobenzoate the inhibitor remains stable after 48 h with all tissues examined. The inhibitor inhibits the closely related endopeptidase EC 3.4.24.15 1/20 to 1/30 as potently as it inhibits EC 3.4.24.15 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumaryl-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl) + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
EP24.15
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000023
-
 N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(alpha-aminoisobutyryl)-Tyr-p-aminobenzoate
-
 Rattus norvegicus