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Literature summary for 3.4.24.15 extracted from

  • Orlowski, M.; Michaud, C.; Chu, T.G.
    A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides (1983), Eur. J. Biochem., 135, 81-88.
    View publication on PubMed
Search for more literature for 3.4.24.15

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Rattus norvegicus
EDTA reactivation by metal ions Rattus norvegicus
EGTA
-
 Rattus norvegicus
NEM
-
 Rattus norvegicus
PCMB
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.031
-
 benzoyl-Gly-Phe-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
0.16
-
 benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
0.22
-
 tert-butoxycarbonyl-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
0.24
-
 benzoyl-Gly-Lys-Arg-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
0.37
-
 benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate
-
 Rattus norvegicus
0.49
-
 benzoyl-Gly-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
0.51
-
 benzoyl-Gly-Phe-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
0.72
-
 benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate
-
 Rattus norvegicus
2
-
 benzoyl-Gly-Gly-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
2.5
-
 benzoyl-Gly-Ala-Ala-Leu-p-aminobenzoate
-
 Rattus norvegicus
3.1
-
 benzoyl-Gly-Ala-Ala-Gly-p-aminobenzoate
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
28.7
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met + H2O cleavage sites: Pro4-Gln5, Phe8-Gly9 and Phe7-Phe8 Rattus norvegicus peptide fragments
-
 ?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O i.e. bradykinin, cleavage site: Phe5-Ser6 Rattus norvegicus Arg-Pro-Pro-Gly-Phe + Ser-Pro-Phe-Arg
-
 ?
benzoyl-Arg-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Arg + Ala-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Asp-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Asp + Ala-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Gly-Ala-Ala-Gly-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly + Ala-Ala-Gly-p-aminobenzoate
-
 ?
benzoyl-Gly-Ala-Ala-Leu-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly + Ala-Ala-Leu-p-aminobenzoate
-
 ?
benzoyl-Gly-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly + Ala-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate + H2O
-
 Rattus norvegicus benzoyl-Gly-Arg + Ala-Ala-Phe-4-aminobenzoate
-
 ?
benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate + H2O
-
 Rattus norvegicus ?
-
 ?
benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate + H2O
-
 Rattus norvegicus benzoyl-Gly-Asp + Ala-Ala-Phe-4-aminobenzoate
-
 ?
benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate + H2O
-
 Rattus norvegicus ?
-
 ?
benzoyl-Gly-Gly-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly + Gly-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Gly-Lys-Arg-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly-Lys-Arg + Ala-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly-Phe + Ala-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Gly-Phe-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly + Phe-Ala-Phe-p-aminobenzoate
-
 ?
benzoyl-Gly-Phe-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus benzoyl-Gly-Phe-Phe + Ala-Ala-Phe-p-aminobenzoate
-
 ?
luliberin
-
 Rattus norvegicus peptide fragments
-
 ?
additional information no hydrolysis of Met-enkephalin Rattus norvegicus ?
-
 ?
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu
-
 Rattus norvegicus pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg + Arg-Pro-Tyr-Ile-Leu
-
 ?
tert-butoxycarbonyl-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus tert-butoxycarbonyl-Phe + Ala-Ala-Phe-p-aminobenzoate
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.15
-
 benzoyl-Gly-Ala-Ala-Gly-p-aminobenzoate
-
 Rattus norvegicus
1.45
-
 benzoyl-Gly-Gly-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
2.2
-
 benzoyl-Gly-Asp-Ala-Ala-Phe-4-aminobenzoate
-
 Rattus norvegicus
2.75
-
 benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
3.1
-
 benzoyl-Gly-Ala-Ala-Leu-p-aminobenzoate
-
 Rattus norvegicus
4.77
-
 benzoyl-Gly-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
5.25
-
 benzoyl-Gly-Arg-Ala-Ala-Phe-4-aminobenzoate
-
 Rattus norvegicus
6.2
-
 benzoyl-Gly-Phe-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
8.6
-
 benzoyl-Gly-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
10.1
-
 benzoyl-Gly-Lys-Arg-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus
21.5
-
 tert-butoxycarbonyl-Phe-Ala-Ala-Phe-p-aminobenzoate
-
 Rattus norvegicus