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Literature summary for 3.4.24.11 extracted from

  • Welches, W.R.; Broshihan, K.B.; Ferrario, C.M.
    A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11 (1993), Life Sci., 52, 1461-1480.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Bos taurus
EDTA
-
Homo sapiens
EDTA
-
Mus musculus
EDTA
-
Oryctolagus cuniculus
EDTA
-
Rattus norvegicus
EDTA
-
Sus scrofa
NaCl brain enzyme; lung enzyme Mus musculus
NaCl no inhibition of the enzyme from brain and kidney Oryctolagus cuniculus
NaCl brain enzyme Rattus norvegicus
phosphoramidon
-
Homo sapiens
phosphoramidon
-
Mus musculus
phosphoramidon
-
Rattus norvegicus
phosphoramidon
-
Sus scrofa
thiol kidney enzyme; lung enzyme Homo sapiens
thiol lung enzyme Mus musculus
thiol kidney enzyme Oryctolagus cuniculus
thiol brain enzyme Rattus norvegicus
thiol intestine enzyme; kidney enzyme Sus scrofa
thiorphan
-
Homo sapiens
thiorphan
-
Mus musculus
thiorphan
-
Rattus norvegicus
thiorphan
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
Tyr-Gly-Gly-Phe-Met
-
Rattus norvegicus
0.022
-
Met-enkephalin
-
Homo sapiens
0.0319
-
Substance P
-
Sus scrofa
0.036
-
angiotensin I
-
Homo sapiens
0.039
-
neurotensin
-
Homo sapiens
0.04
-
Met-enkephalin
-
Bos taurus
0.062
-
Met5-enkephalin
-
Sus scrofa
0.074
-
Leu-enkephalin
-
Homo sapiens
0.078
-
neurotensin
-
Sus scrofa
0.086
-
Leu5-enkephalin
-
Sus scrofa
0.092
-
bradykinin
-
Rattus norvegicus
0.092
-
bradykinin
-
Sus scrofa
0.12
-
bradykinin
-
Oryctolagus cuniculus
0.162
-
bradykinin
-
Homo sapiens
0.19
-
Substance P
-
Homo sapiens
0.755
-
Luteinizing hormone-releasing hormone
-
Rattus norvegicus
0.755
-
Luteinizing hormone-releasing hormone
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
kidney
-
Oryctolagus cuniculus
-
lung
-
Rattus norvegicus
-
lung
-
Sus scrofa
-
testis
-
Rattus norvegicus
-
testis
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens ?
-
?
angiotensin I + H2O
-
Rattus norvegicus ?
-
?
angiotensin I + H2O
-
Oryctolagus cuniculus ?
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Homo sapiens ?
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Rattus norvegicus ?
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Sus scrofa ?
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Oryctolagus cuniculus ?
-
?
bradykinin + H2O
-
Homo sapiens ?
-
?
bradykinin + H2O
-
Rattus norvegicus ?
-
?
bradykinin + H2O
-
Sus scrofa ?
-
?
bradykinin + H2O
-
Oryctolagus cuniculus ?
-
?
Leu5-enkephalin + H2O
-
Homo sapiens ?
-
?
Leu5-enkephalin + H2O
-
Rattus norvegicus ?
-
?
Leu5-enkephalin + H2O
-
Sus scrofa ?
-
?
Leu5-enkephalin + H2O
-
Bos taurus ?
-
?
Leu5-enkephalin + H2O
-
Oryctolagus cuniculus ?
-
?
Luteinizing hormone-releasing hormone + H2O
-
Homo sapiens ?
-
?
Luteinizing hormone-releasing hormone + H2O
-
Rattus norvegicus ?
-
?
Luteinizing hormone-releasing hormone + H2O
-
Sus scrofa ?
-
?
Luteinizing hormone-releasing hormone + H2O
-
Oryctolagus cuniculus ?
-
?
neurotensin + H2O
-
Homo sapiens ?
-
?
neurotensin + H2O
-
Rattus norvegicus ?
-
?
neurotensin + H2O
-
Sus scrofa ?
-
?
neurotensin + H2O
-
Oryctolagus cuniculus ?
-
?
Substance P + H2O
-
Homo sapiens ?
-
?
Substance P + H2O
-
Sus scrofa ?
-
?
Tyr-Gly-Gly-Phe-Met + H2O i.e. methionine enkephalin Homo sapiens Tyr-Gly-Gly + Phe-Met
-
?
Tyr-Gly-Gly-Phe-Met + H2O i.e. methionine enkephalin Rattus norvegicus Tyr-Gly-Gly + Phe-Met
-
?
Tyr-Gly-Gly-Phe-Met + H2O i.e. methionine enkephalin Sus scrofa Tyr-Gly-Gly + Phe-Met
-
?
Tyr-Gly-Gly-Phe-Met + H2O i.e. methionine enkephalin Bos taurus Tyr-Gly-Gly + Phe-Met
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
kidney enzyme Oryctolagus cuniculus
6.5
-
kidney enzyme Homo sapiens
6.5 7 brain enzyme Rattus norvegicus
7 7.5 kidney enzyme Sus scrofa
7
-
-
Mus musculus
7
-
-
Rattus norvegicus
7
-
intestine Sus scrofa
7
-
kidney Homo sapiens
8
-
-
Rattus norvegicus