Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(3-iodohydroxy)phenylmethyl]-4-N-[3-hydroxyamino-3-oxo-1-phenylmethylpropyl]-amino-4-oxobutanoic acid | i.e. RB104, highly selective and potent inhibitor | Canis lupus familiaris | |
phosphoramidon | - |
Canis lupus familiaris | |
thiorphan | - |
Canis lupus familiaris |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
D-Ala2-Leu5-enkephalin | enzyme from tubules | Canis lupus familiaris | |
0.076 | - |
D-Ala2-Leu5-enkephalin | enzyme from glomeruli | Canis lupus familiaris |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | glomerular enzyme is membrane-bound | Canis lupus familiaris | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
94000 | - |
x * 94000, enzyme from tubules, SDS-PAGE | Canis lupus familiaris |
104000 | - |
x * 104000, enzyme from glomeruli, SDS-PAGE | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Canis lupus familiaris | the enzyme may play an important role as regulator of plasma-derived peptides in the nephron | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | glycoprotein | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | glomeruli, tubules | Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ala2-Leu5-enkephalin + H2O | i.e. Tyr-D-Ala-Gly-Phe-Leu | Canis lupus familiaris | Tyr-D-Ala-Gly + Phe-Leu | - |
? | |
additional information | the enzyme may play an important role as regulator of plasma-derived peptides in the nephron | Canis lupus familiaris | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 94000, enzyme from tubules, SDS-PAGE | Canis lupus familiaris |
? | x * 104000, enzyme from glomeruli, SDS-PAGE | Canis lupus familiaris |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
19 | - |
D-Ala2-Leu5-enkephalin | enzyme from tubules | Canis lupus familiaris | |
20.7 | - |
D-Ala2-Leu5-enkephalin | enzyme from glomeruli | Canis lupus familiaris |