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Literature summary for 3.4.24.11 extracted from
- Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides (1989), Biochim. Biophys. Acta, 996, 82-88.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.033 | - |
unsulfated cholecystokinin octapeptide | - |
Homo sapiens |  |
| 0.049 | - |
gastrin G-17 | sulfated | Homo sapiens | |
| 0.057 | - |
sulfated cholecystokinin octapeptide | - |
Homo sapiens | |
| 0.068 | - |
gastrin G-17 | unsulfated | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is responsible for the difference in metabolism of sulfated and unsulfated gastrin in human circulation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Homo sapiens | ? | - |
? | |
| cholecystokinin-8 + H2O | - |
Homo sapiens | ? | - |
? | |
| gastrin G-17 + H2O | cleavage at four sites, Trp4-Leu5, Ala11-Tyr12, Gly13-Trp14 and Asp16-Phe17 | Homo sapiens | ? | - |
? | |
| gastrin G-17 + H2O | sulfated and unsulfated gastrin, cleavage is faster with the sulfated peptide | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is responsible for the difference in metabolism of sulfated and unsulfated gastrin in human circulation | Homo sapiens | ? | - |
? | |
| sulfated cholecystokinin octapeptide + H2O | - |
Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.767 | - |
gastrin G-17 | sulfated | Homo sapiens | |
| 1.07 | - |
gastrin G-17 | unsulfated | Homo sapiens | |
| 24.6 | - |
unsulfated cholecystokinin octapeptide | - |
Homo sapiens | |
| 31.1 | - |
sulfated cholecystokinin octapeptide | - |
Homo sapiens | |
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