Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR enzyme expression analysis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
thiorphan | a NEP-specific inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P07861 | - |
- |
Rattus norvegicus Wistar-Hannover | P07861 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia | Rattus norvegicus | - |
additional information | expression and activity of NEP in cognitive-related brain structures of rats submitted to chronic intermittent hypoxia (CIH) | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala-Phe + 7-amino-4-methylcoumarin | - |
? | |
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus Wistar-Hannover | succinyl-Ala-Ala-Phe + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEP | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia | up |
General Information | Comment | Organism |
---|---|---|
physiological function | neprilysin (NEP) is responsible for degrading several substrates related to cognition | Rattus norvegicus |