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Literature summary for 3.4.24.11 extracted from

  • Ul-Haq, Z.; Usmani, S.; Iqbal, S.; Zia, S.R.
    In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity (2016), Mol. Biosyst., 12, 1024-1036 .
    View publication on PubMed
Search for more literature for 3.4.24.11

Inhibitors

Inhibitors Comment Organism Structure
fasidotrilat fasidotrilat interacts with the Arg664 of hNEP with more consistent bidentate hydrogen bonding and with the His658 with monodentate hydrogen bonding Homo sapiens
additional information molecular docking studies, overview. For substrate and inhibitor binding, Arg664 and Zn697 are identified as the most conserved residues Homo sapiens
N-[(2S)-3-phenyl-2-(sulfanylmethyl)propanoyl]-L-tryptophan
-
 Homo sapiens
omapatrilat
-
 Homo sapiens
phosphoramidon strong, consistent interactions with Arg664, Glu531 and His658 of hNEP Homo sapiens
thiorphan Arg49 and Arg664 act to support the ligand binding in NEP Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08473
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
peripheral blood
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
NEP
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000008
-
 phosphoramidon pH and temperature not specified in the publication Homo sapiens
0.000003
-
 omapatrilat pH and temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
evolution sequence comparisons of NEP and NEP-2 (EC 3.4.24._) Homo sapiens
evolution sequence comparisons of NEP and NEP-2 Homo sapiens
malfunction inhibitors of NEP with a lesser degree of specificity can treat hypertension with an increased risk of cerebral deposition of amyloid-beta Homo sapiens
metabolism in the peripheral system, neutral endopeptidase neprilysin (NEP) regulates hypertension and heart related diseases, while its closest homologue, neprilysin-2 (NEP2, EC 3.4.24._), in the central nervous system controls Alzheimer's protein (amyloid-beta) deposition, and prevents its occurrence Homo sapiens
metabolism in the peripheral system, neutral endopeptidase neprilysin (NEP) regulates hypertension and heart related diseases, while its closest homologue, neprilysin-2 (NEP2), in the central nervous system controls Alzheimer's protein (amyloid-beta) deposition, and prevents its occurrence Homo sapiens
additional information molecular dynamics (MD) simulations of NEP and modelling, overview. For substrate and inhibitor binding, Arg664 and Zn697 are identified as the most conserved residues Homo sapiens
physiological function neutral endopeptidase neprilysin (NEP) regulates hypertension and heart related diseases Homo sapiens