Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphoramidon | - |
Homo sapiens | |
phosphoramidon | the inhibitor induces a dramatic increase in amyloid-beta peptide levels | Mus musculus | |
phosphoramidon | the inhibitor induces a dramatic increase in amyloid-beta peptide levels | Rattus norvegicus | |
thiorphan | - |
Homo sapiens | |
thiorphan | the inhibitor induces a dramatic increase in amyloid-beta peptide levels | Mus musculus | |
thiorphan | the inhibitor induces a dramatic increase in amyloid-beta peptide levels | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | neprilysin is a zinc metalloendopeptidase | Rattus norvegicus | |
Zn2+ | neprilysin is a zinc metalloendopeptidase | Homo sapiens | |
Zn2+ | neprilysin is a zinc metalloendopeptidase | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta peptide Abeta42 + H2O | Rattus norvegicus | the peptide primarily undergoes degradation by NEP in vivo in the brain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08473 | - |
- |
Mus musculus | Q61391 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta peptide Abeta42 + H2O | the peptide primarily undergoes degradation by NEP in vivo in the brain | Rattus norvegicus | ? | - |
? | |
additional information | human neprilysin-2 has a more restricted substrate specificity compared to human neprilysin with less activity against several vasoactive peptides | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEP | - |
Rattus norvegicus |
NEP | - |
Homo sapiens |
NEP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | neprilysin is a zinc metalloendopeptidase belonging to the M13 family | Rattus norvegicus |
evolution | neprilysin is a zinc metalloendopeptidase belonging to the M13 family | Homo sapiens |
evolution | neprilysin is a zinc metalloendopeptidase belonging to the M13 family | Mus musculus |
malfunction | application of inhibitors to NEP in mouse brain produced dramatic elevations of endogenous amyloid beta peptide resulting in plaque deposition. But enzyme knockout mice show only a moderate increase in amyloid beta levels that are far from the levels needed to induce plaque deposition. This modest increase in amyloid beta peptide raises the possibility of alternative amyloid beta degrading-enzymes that are likewise sensitive to NEP-inhibitors | Mus musculus |
malfunction | application of inhibitors to NEP in rat brain produced dramatic elevations of endogenous amyloid beta peptide resulting in plaque deposition | Rattus norvegicus |
metabolism | neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP) to control amyloid-beta peptide levels in the brain | Rattus norvegicus |
metabolism | neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP) to control amyloid-beta peptide levels in the brain | Homo sapiens |
metabolism | neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP) to control amyloid-beta peptide levels in the brain | Mus musculus |