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Literature summary for 3.4.24.11 extracted from

  • Marr, R.A.; Hafez, D.M.
    Amyloid-beta and Alzheimers disease: the role of neprilysin-2 in amyloid-beta clearance (2014), Front. Aging Neurosci., 6, 187.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
Homo sapiens
phosphoramidon the inhibitor induces a dramatic increase in amyloid-beta peptide levels Mus musculus
phosphoramidon the inhibitor induces a dramatic increase in amyloid-beta peptide levels Rattus norvegicus
thiorphan
-
Homo sapiens
thiorphan the inhibitor induces a dramatic increase in amyloid-beta peptide levels Mus musculus
thiorphan the inhibitor induces a dramatic increase in amyloid-beta peptide levels Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ neprilysin is a zinc metalloendopeptidase Rattus norvegicus
Zn2+ neprilysin is a zinc metalloendopeptidase Homo sapiens
Zn2+ neprilysin is a zinc metalloendopeptidase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta peptide Abeta42 + H2O Rattus norvegicus the peptide primarily undergoes degradation by NEP in vivo in the brain ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08473
-
-
Mus musculus Q61391
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain
-
Homo sapiens
-
brain
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta peptide Abeta42 + H2O the peptide primarily undergoes degradation by NEP in vivo in the brain Rattus norvegicus ?
-
?
additional information human neprilysin-2 has a more restricted substrate specificity compared to human neprilysin with less activity against several vasoactive peptides Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
NEP
-
Rattus norvegicus
NEP
-
Homo sapiens
NEP
-
Mus musculus

General Information

General Information Comment Organism
evolution neprilysin is a zinc metalloendopeptidase belonging to the M13 family Rattus norvegicus
evolution neprilysin is a zinc metalloendopeptidase belonging to the M13 family Homo sapiens
evolution neprilysin is a zinc metalloendopeptidase belonging to the M13 family Mus musculus
malfunction application of inhibitors to NEP in mouse brain produced dramatic elevations of endogenous amyloid beta peptide resulting in plaque deposition. But enzyme knockout mice show only a moderate increase in amyloid beta levels that are far from the levels needed to induce plaque deposition. This modest increase in amyloid beta peptide raises the possibility of alternative amyloid beta degrading-enzymes that are likewise sensitive to NEP-inhibitors Mus musculus
malfunction application of inhibitors to NEP in rat brain produced dramatic elevations of endogenous amyloid beta peptide resulting in plaque deposition Rattus norvegicus
metabolism neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP) to control amyloid-beta peptide levels in the brain Rattus norvegicus
metabolism neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP) to control amyloid-beta peptide levels in the brain Homo sapiens
metabolism neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP) to control amyloid-beta peptide levels in the brain Mus musculus