Inhibitors | Comment | Organism | Structure |
---|---|---|---|
thiorphan | - |
Homo sapiens | |
U46619 | a thromboxane mimetic | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | located on the lung surface | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pulmonary vasodilative vasoactive intestinal peptide + H2O | Homo sapiens | rapid inactivation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08473 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pulmonary vasodilative vasoactive intestinal peptide + H2O | rapid inactivation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEP | - |
Homo sapiens |
neutral endopeptidase | - |
Homo sapiens |
neutral endopeptidase 24.11 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition augmentes the maximum hemodynamic effects of pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, aerosol, and also leads to a significant prolongation of these effects | Homo sapiens |
physiological function | the enzyme inhibits the pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, in lungs of subjects with pathophysiology of pulmonary hypertension (due to a deficiency in VIP) by rapid inactivation of VIP | Homo sapiens |