Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.11 extracted from

  • Leuchte, H.H.; Prechtl, C.; Callegari, J.; Meis, T.; Haziraj, S.; Bevec, D.; Behr, J.
    Augmentation of the effects of vasoactive intestinal peptide aerosol on pulmonary hypertension via coapplication of a neutral endopeptidase 24.11 inhibitor (2015), Am. J. Physiol. Lung Cell Mol. Physiol., 308, L563-L568.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
thiorphan
-
Homo sapiens
U46619 a thromboxane mimetic Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular located on the lung surface Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pulmonary vasodilative vasoactive intestinal peptide + H2O Homo sapiens rapid inactivation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08473
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pulmonary vasodilative vasoactive intestinal peptide + H2O rapid inactivation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
NEP
-
Homo sapiens
neutral endopeptidase
-
Homo sapiens
neutral endopeptidase 24.11
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition augmentes the maximum hemodynamic effects of pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, aerosol, and also leads to a significant prolongation of these effects Homo sapiens
physiological function the enzyme inhibits the pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, in lungs of subjects with pathophysiology of pulmonary hypertension (due to a deficiency in VIP) by rapid inactivation of VIP Homo sapiens