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Literature summary for 3.4.24.11 extracted from
- Neprilysin-2 is an important beta-amyloid degrading enzyme (2011), Am. J. Pathol., 178, 306-312.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NEP | - |
Mus musculus |
| neprilysin | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in NEP/NEP2 double-knockout mice, amyloid-beta peptide levels are marginally increased (1.5 to 2fold), compared with NEP-/-/NEP2+/+ controls. Treatment of these double-knockout mice with phosphoramidon results in elevations of amyloid-beta peptide, suggesting that yet other NEP-like amyloid-beta peptide -degrading endopeptidases are contributing to amyloid-beta peptide catabolism | Mus musculus |
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Release 2023.1 (January 2023)
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