Literature summary for 3.4.24.11 extracted from

Ruilope, L.M.; Dukat, A.; Boehm, M.; Lacourciere, Y.; Gong, J.; Lefkowitz, M.P.
Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study (2010), Lancet, 375, 1255-1266.

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Inhibitors

Inhibitors	Comment	Organism	Structure
LCZ696	LCZ696 is a dual-acting angiotensin II-receptor and neprilysin inhibitor (ARNI) in a single molecule: angiotensin-receptor blockade via its valsartan molecular moiety, and neprilysin inhibition via its AHU377 molecular moiety. In a randomized, double-blind, placebo-controlled, active comparator study it is shown that compared with valsartan, dual-acting LCZ696 provides complementary and fully additive reduction of blood pressure	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
neprilysin	-	Homo sapiens

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Release 2023.1 (January 2023)