Cloned (Comment) | Organism |
---|---|
expressed as a GST-fusion protein in Escherichia coli | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphoramidon | - |
Drosophila melanogaster | |
thiorphan | - |
Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | isoform A is expressed as a membrane bound protein | Drosophila melanogaster | 16020 | - |
soluble | isoform B is expressed as a soluble protein | Drosophila melanogaster | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
113000 | - |
isoform B, SDS-PAGE using purified NEP4 antiserum | Drosophila melanogaster |
120000 | - |
isoform A, SDS-PAGE using purified NEP4 antiserum | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Drosophila melanogaster | Q9I7I4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | 51.6% degradation | Drosophila melanogaster | ? | - |
? | |
bradykinin + H2O | 27.8% degradation | Drosophila melanogaster | ? | - |
? | |
Substance P + H2O | 85.8% degradation | Drosophila melanogaster | ? | - |
? | |
tachykinin + H2O | 27.8% degradation | Drosophila melanogaster | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEP4A | - |
Drosophila melanogaster |
NEP4B | - |
Drosophila melanogaster |
neprilysin 4 | two isoforms exist due to different splice-variants: larger isoform A is expressed as a membrane bound protein and isoform B lacking the N-terminal cytosolic and transmembrane region is expressed as a soluble protein | Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | - |
assay at | Drosophila melanogaster |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Drosophila melanogaster |