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Literature summary for 3.4.24.11 extracted from

  • Meyer, H.; Panz, M.; Zmojdzian, M.; Jagla, K.; Paululat, A.
    Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility states (2009), J. Exp. Biol., 212, 3673-3683.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed as a GST-fusion protein in Escherichia coli Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
Drosophila melanogaster
thiorphan
-
Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane isoform A is expressed as a membrane bound protein Drosophila melanogaster 16020
-
soluble isoform B is expressed as a soluble protein Drosophila melanogaster
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
113000
-
isoform B, SDS-PAGE using purified NEP4 antiserum Drosophila melanogaster
120000
-
isoform A, SDS-PAGE using purified NEP4 antiserum Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Drosophila melanogaster Q9I7I4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O 51.6% degradation Drosophila melanogaster ?
-
?
bradykinin + H2O 27.8% degradation Drosophila melanogaster ?
-
?
Substance P + H2O 85.8% degradation Drosophila melanogaster ?
-
?
tachykinin + H2O 27.8% degradation Drosophila melanogaster ?
-
?

Synonyms

Synonyms Comment Organism
NEP4A
-
Drosophila melanogaster
NEP4B
-
Drosophila melanogaster
neprilysin 4 two isoforms exist due to different splice-variants: larger isoform A is expressed as a membrane bound protein and isoform B lacking the N-terminal cytosolic and transmembrane region is expressed as a soluble protein Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
assay at Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Drosophila melanogaster