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Literature summary for 3.4.24.11 extracted from

  • Liang, K.; Yang, L.; Yin, C.; Xiao, Z.; Zhang, J.; Liu, Y.; Huang, J.
    Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin (2010), J. Biol. Chem., 285, 935-942.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
estrogen estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell line in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid peptide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
neprilysin
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen. Upregulation of neprilysin by estrogen is dependent on both estrogen receptor alpha and beta, and ligand-activated estrogen receptor regulates expression of neprilysin through physical interactions between estrogen receptor and estrogen response elements identified in the neprilysin gene up