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Literature summary for 3.4.24.11 extracted from

  • Davidson, E.; Coppey, L.; Lu, B.; Arballo, V.; Calcutt, N.A.; Gerard, C.; Yorek, M.
    The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy (2009), Exp. Diabetes Res., 2009, 431980.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
NEP
-
Mus musculus
neutral endopeptidase
-
Mus musculus

General Information

General Information Comment Organism
malfunction the role of NEP in neuropathy related to either insulin-deficient diabetes or diet-induced obesity using NEP deficient (-/-) mice is explored. Glucose disposal is impaired in both C57Bl/6 and NEP -/- mice fed a high fat diet. Thermal hypoalgesia and nerve conduction slowing are present in both streptozotocin-diabetic and high fat fed C57Bl/6 mice but not in NEP -/- mice exposed to either streptozotocin-induced diabetes or a high fat diet Mus musculus