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Literature summary for 3.4.24.11 extracted from

  • Maeshiro, K.; Takamori, S.; Mifune, H.; Matsuo, T.; Kimura, N.Y.; Honda, J.; Shirouzu, K.
    Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis (2008), Surg. Today, 38, 130-134.
    View publication on PubMed

Application

Application Comment Organism
pharmacology inhibitor thiorphan might be effective for reducing elevated A-type natriuretic peptide levels in sepsis. Plasma and lung A-type natriuretic peptide levels in rats treated with lipopolysaccharide are significantly higher than those in the control group, but are significantly decreased by thiorphan administration. Natriuretic peptide receptor-A mRNA levels do not differ significantly among the groups. Natriuretic peptide receptor-C mRNA levels in animals treated with lipopolysaccharide plus thiorphan group are significantly higher than those in the other groups Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
thiorphan plasma and lung A-type natriuretic peptide levels in rats treated with lipopolysaccharide are significantly higher than those in the control group, but are significantly decreased by thiorphan administration. Natriuretic peptide receptor-A mRNA levels do not differ significantly among the groups. Natriuretic peptide receptor-C mRNA levels in animals treated with lipopolysaccharide plus thiorphan group are significantly higher than those in the other groups Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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