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Literature summary for 3.4.24.11 extracted from

  • Burgos-Ramos, E.; Puebla-Jimenez, L.; Arilla-Ferreiro, E.
    Minocycline prevents Abeta(25-35)-induced reduction of somatostatin and neprilysin content in rat temporal cortex (2009), Life Sci., 84, 205-210.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
minocycline minocycline abrogates the amyloid beta(25-35)-induced decrease of somatostatin-like immunoreactive content, somatostatin mRNA levels, phosphorylated-cAMP-response element binding protein CREB content and neprilysin levels. Minocycline alone enhances these targets Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
amyloid beta infusion with amyloid beta(25-35) induces decrease of somatostatin-like immunoreactive content, somatostatin mRNA levels, phosphorylated-cAMP-response element binding protein CREB content and neprilysin levels Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
brain temporal cortex of amyloid beta(25-35)-infused and healthy rats Rattus norvegicus
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