Activating Compound | Comment | Organism | Structure |
---|---|---|---|
androgen | androgens positively regulate neural expression of neprilysin in adult male rats | Rattus norvegicus | |
dihydrotestosterone | induces a time-dependent increase in neprilysin expression. Dihydrotestosterone also significantly decreases levels of amyloid beta in androgen receptor-expressing cells transfected with amyloid precursor protein, but does not affect levels of either full-length or non-amyloidogenic, soluble amyloid precursor protein. The dihydrotestosterone-induced decrease of amyloid beta is blocked by pharmacological inhibition of neprilysin. The dihydrotestosterone-mediated increase in neprilysin expression and decrease in amyloid beta levels are not observed in rat pheochromocytoma cell 12 lacking androgen receptor and blocked in androgen receptor-expressing cells by the antagonists, cyproterone acetate and flutamide | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
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Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | androgens positively regulate neural expression of neprilysin in adult male rats | Rattus norvegicus | - |