Literature summary for 3.4.24.11 extracted from

Bukowska, A.; Lendeckel, U.; Krohn, A.; Keilhoff, G.; ten Have, S.; Neumann, K.H.; Goette, A.
Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney (2008), Europace, 10, 1212-1217.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	renal mRNA expression and protein of neprilysin is substantially downregulated during rapid atrial pacing. Irbesartan therapy does not prevent down-regulation of neprilysin. In contrast, TGF-beta1 mRNA expression is up-regulated. Collagen and angiotensin II type 1 receptor expression are not significantly altered by rapid atrial pacing. Application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro	Sus scrofa	-

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Release 2023.1 (January 2023)