Literature summary for 3.4.24.11 extracted from

Chen, K.L.; Wang, S.S.; Yang, Y.Y.; Yuan, R.Y.; Chen, R.M.; Hu, C.J.
The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells (2009), Biochem. Biophys. Res. Commun., 378, 57-61.

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Inhibitors

Inhibitors	Comment	Organism	Structure
amyloid beta	amyloid beta reduces global DNA methylation whilst increasing neprilysin DNA methylation and further suppressing the neprilysin expression in mRNA and protein levels. Amyloid beta induces epigenetic effects, implying that DNA methylation may be part of a vicious cycle involving the reduction in neprilysin expression along with a resultant increase in amyloid beta accumulation, and that amyloiud beta may induce global DNA hypo-methylation	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	cerebral endothelial cell culture	Mus musculus	-

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Release 2023.1 (January 2023)