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Literature summary for 3.4.23.B9 extracted from
- Inhibition of activity of the protease from bovine leukemia virus (1994), FEBS Lett., 346, 268-272.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ac-PQVL-azetidine-VM | IC50: 0.25 mM | bovine leukemia virus |  |
| Ac-PQVL-pipecolic acid-VM | IC50: 0.015 mM | bovine leukemia virus | |
| pepstatin A | IC50: 0.3-0.5 mM | bovine leukemia virus | |
| PQV-statine-AI | IC50: 0.1 mM | bovine leukemia virus | |
| YDPPAI-statine-II | IC50: 0.0005 mM | bovine leukemia virus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | bovine leukemia virus | the enzyme is responsible for processing both the initial translation products - precursors Gag-Pro-Pol, Gag-Pro and Gag into functional enzymes - protease, reverse transcriptase and integrase - and the mature structural proteins of the matrix, capsid and nucleocapsid | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| bovine leukemia virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AELE-aminobutyric acid-LLSIPLA + H2O | 70% of the activity with YDPPAILPII | bovine leukemia virus | AELE-aminobutyric acid-L + LSIPLA | - |
? | |
| APQVLPVMHP + H2O | - |
bovine leukemia virus | APQVL + PVMHP | - |
? | |
| KGPPVILPIQDP + H2O | - |
bovine leukemia virus | KGPPVIL + PIQDP | - |
? | |
| additional information | the enzyme is responsible for processing both the initial translation products - precursors Gag-Pro-Pol, Gag-Pro and Gag into functional enzymes - protease, reverse transcriptase and integrase - and the mature structural proteins of the matrix, capsid and nucleocapsid | bovine leukemia virus | ? | - |
? | |
| YDPPAILPII + H2O | - |
bovine leukemia virus | YDPPAIL + PII | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
IC50: 0.0005 mM | bovine leukemia virus | YDPPAI-statine-II | |
| 0.015 | - |
IC50: 0.015 mM | bovine leukemia virus | Ac-PQVL-pipecolic acid-VM | |
| 0.1 | - |
IC50: 0.1 mM | bovine leukemia virus | PQV-statine-AI | |
| 0.25 | - |
IC50: 0.25 mM | bovine leukemia virus | Ac-PQVL-azetidine-VM | |
| 0.3 | 0.5 | IC50: 0.3-0.5 mM | bovine leukemia virus | pepstatin A | |
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