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Literature summary for 3.4.23.B8 extracted from

  • Nguyen, J.T.; Kato, K.; Hidaka, K.; Kumada, H.O.; Kimura, T.; Kiso, Y.
    Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles (2011), Bioorg. Med. Chem. Lett., 21, 2425-2429.
    View publication on PubMed
Search for more literature for 3.4.23.B8

Crystallization (Commentary)

Crystallization (Comment) Organism
computer-assisted modeling using inhibitors N2-[(2S)-2-(b-alanylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide and N2-[(2S)-2-(butanoylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide Human T-cell leukemia virus type I

Protein Variants

Protein Variants Comment Organism
L40I mutant used for inhibitor screening Human T-cell leukemia virus type I

Inhibitors

Inhibitors Comment Organism Structure
N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-N2-[(2S)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-3-methyl-L-valinamide
-
 Human T-cell leukemia virus type I
N-[(2S)-4-[(4R)-4-[(2-tert-butylhydrazinyl)carbonyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-N2-[(2S)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-3-methyl-L-valinamide
-
 Human T-cell leukemia virus type I
N2-[(2S)-2-(b-alanylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide
-
 Human T-cell leukemia virus type I
N2-[(2S)-2-(butanoylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide
-
 Human T-cell leukemia virus type I

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000057
-
 recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication Human T-cell leukemia virus type I N2-[(2S)-2-(b-alanylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide
0.0000064
-
 recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication Human T-cell leukemia virus type I N2-[(2S)-2-(butanoylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide
0.0000072
-
 recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-N2-[(2S)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-3-methyl-L-valinamide
0.0000104
-
 recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2S)-4-[(4R)-4-[(2-tert-butylhydrazinyl)carbonyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-N2-[(2S)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-3-methyl-L-valinamide