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Literature summary for 3.4.23.B8 extracted from

  • Nguyen, J.T.; Zhang, M.; Kumada, H.O.; Itami, A.; Nishiyama, K.; Kimura, T.; Cheng, M.; Hayashi, Y.; Kiso, Y.
    Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 366-370.
    View publication on PubMed
Search for more literature for 3.4.23.B8

Inhibitors

Inhibitors Comment Organism Structure
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2,2-dimethylpropyl)amino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2-methylprop-2-en-1-yl)amino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2-methylpropyl)amino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((cyclopropyl)amino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(2-methylbenzylamino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(3-iodobenzylamino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(prop-2-en-1-ylamino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(propylamino)
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Gln-NH2
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-NH2
-
 Human T-cell leukemia virus type I
acetyl-(L-(+)-alpha-phenylglycine)-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-(L-tert-leucine)-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-Gln-Val-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Val-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-(L-(+)-alpha-phenylglycine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(L-(+)-alpha-phenylglycine)-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(L-tert-leucine)-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Ala-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Gln-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Phe-NH2
-
 Human T-cell leukemia virus type I
acetyl-Ile-Ile-(phenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
-
 Human T-cell leukemia virus type I
Pro-Gln-Val-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Val-Met-His-Pro
-
 Human T-cell leukemia virus type I
Pro-Gln-Val-allophenylnorstatine-Pro-Val-Met-His-Pro
-
 Human T-cell leukemia virus type I

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
PQVLPVMHP + H2O
-
 Human T-cell leukemia virus type I PQVL + PVMHP
-
 ?

Synonyms

Synonyms Comment Organism
HTLV-I protease
-
 Human T-cell leukemia virus type I

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000084
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Gln-NH2
0.000088
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.000095
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Phe-NH2
0.000101
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.000102
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.000103
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(2-methylbenzylamino)
0.000107
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2-methylpropyl)amino)
0.000113
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2,2-dimethylpropyl)amino)
0.000123
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(L-(+)-alpha-phenylglycine)-Met-NH2
0.000131
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(prop-2-en-1-ylamino)
0.00014
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2-methylprop-2-en-1-yl)amino)
0.000144
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-NH2
0.000145
-
-
 Human T-cell leukemia virus type I acetyl-Ile-(L-(+)-alpha-phenylglycine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.000146
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((cyclopropyl)amino)
0.000152
-
-
 Human T-cell leukemia virus type I Pro-Gln-Val-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Val-Met-His-Pro
0.000159
-
-
 Human T-cell leukemia virus type I Pro-Gln-Val-allophenylnorstatine-Pro-Val-Met-His-Pro
0.000159
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Gln-NH2
0.00016
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Ala-NH2
0.00018
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(phenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.00018
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(L-tert-leucine)-Met-NH2
0.000193
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(propylamino)
0.000201
-
-
 Human T-cell leukemia virus type I acetyl-(L-tert-leucine)-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.000249
-
-
 Human T-cell leukemia virus type I acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-NH2
0.00032
-
-
 Human T-cell leukemia virus type I acetyl-Ile-(L-(+)-alpha-phenylglycine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2
0.000353
-
-
 Human T-cell leukemia virus type I acetyl-Gln-Val-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Val-Met-NH2
0.000473
-
-
 Human T-cell leukemia virus type I acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(3-iodobenzylamino)